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Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome.

Wong HR, Shanley TP, Sakthivel B, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Tagavilla MA, Odoms K, Dunsmore K, Barnes M, Aronow BJ; Genomics of Pediatric SIRS/Septic Shock Investigators.

Physiol Genomics. 2007 Jul 18;30(2):146-55. Epub 2007 Mar 20.


Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.

Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A, Hotchkiss RS.

FASEB J. 2007 Mar;21(3):708-19. Epub 2007 Feb 16.


PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways.

Mi H, Guo N, Kejariwal A, Thomas PD.

Nucleic Acids Res. 2007 Jan;35(Database issue):D247-52. Epub 2006 Nov 27.


Zinc homeostasis and immunity.

Rink L, Haase H.

Trends Immunol. 2007 Jan;28(1):1-4. Epub 2006 Nov 28.


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J, Herndon JM, Davis CG, Muenzer JT, Hotchkiss RS, Ferguson TA.

J Immunol. 2006 Dec 1;177(11):7968-73.


Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL.

J Immunol. 2006 Dec 1;177(11):7943-9.


Gene expression patterns in blood leukocytes discriminate patients with acute infections.

Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, Wittkowski KM, Piqueras B, Banchereau J, Palucka AK, Chaussabel D.

Blood. 2007 Mar 1;109(5):2066-77. Epub 2006 Nov 14.


Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools.

Thomas PD, Kejariwal A, Guo N, Mi H, Campbell MJ, Muruganujan A, Lazareva-Ulitsky B.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W645-50.


Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.

Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, Hirano T.

Nat Immunol. 2006 Sep;7(9):971-7. Epub 2006 Aug 6.


Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst SJ, Grayson MH, DiPasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA, Hotchkiss RS.

J Immunol. 2006 Jul 1;177(1):557-65.


Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study.

Pachot A, Lepape A, Vey S, Bienvenu J, Mougin B, Monneret G.

Immunol Lett. 2006 Jul 15;106(1):63-71. Epub 2006 May 17.


TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.

Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bähr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D.

J Immunol. 2006 May 1;176(9):5471-7.


Intensive insulin therapy in the medical ICU.

Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R.

N Engl J Med. 2006 Feb 2;354(5):449-61.


A network-based analysis of systemic inflammation in humans.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF; Inflamm and Host Response to Injury Large Scale Collab. Res. Program.

Nature. 2005 Oct 13;437(7061):1032-7. Epub 2005 Aug 31. Erratum in: Nature. 2005 Dec 1;438(7068):696.


Scope and epidemiology of pediatric sepsis.

Watson RS, Carcillo JA.

Pediatr Crit Care Med. 2005 May;6(3 Suppl):S3-5. Review.


Leukocyte apoptosis and its significance in sepsis and shock.

Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A.

J Leukoc Biol. 2005 Aug;78(2):325-37. Epub 2005 Apr 7. Review.


Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.

Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE.

J Immunol. 2005 Apr 15;174(8):5110-8.


Application of genome-wide expression analysis to human health and disease.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4801-6. Epub 2005 Mar 21.


Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure.

Felmet KA, Hall MW, Clark RS, Jaffe R, Carcillo JA.

J Immunol. 2005 Mar 15;174(6):3765-72.


International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.

Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis.

Pediatr Crit Care Med. 2005 Jan;6(1):2-8. Review.

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