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Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.

Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW.

Antimicrob Agents Chemother. 2007 Jan;51(1):48-53. Epub 2006 Nov 6.


Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency.

Halvas EK, Aldrovandi GM, Balfe P, Beck IA, Boltz VF, Coffin JM, Frenkel LM, Hazelwood JD, Johnson VA, Kearney M, Kovacs A, Kuritzkes DR, Metzner KJ, Nissley DV, Nowicki M, Palmer S, Ziermann R, Zhao RY, Jennings CL, Bremer J, Brambilla D, Mellors JW.

J Clin Microbiol. 2006 Jul;44(7):2612-4.


Update of the drug resistance mutations in HIV-1: Fall 2005.

Johnson VA, Brun-Vezinet F, Clotet B, Conway B, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman DD.

Top HIV Med. 2005 Oct-Nov;13(4):125-31.


Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision.

Nikolenko GN, Palmer S, Maldarelli F, Mellors JW, Coffin JM, Pathak VK.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2093-8. Epub 2005 Jan 31.


Human immunodeficiency virus reverse transcriptase and protease sequence database.

Rhee SY, Gonzales MJ, Kantor R, Betts BJ, Ravela J, Shafer RW.

Nucleic Acids Res. 2003 Jan 1;31(1):298-303.


Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Sarafianos SG, Clark AD Jr, Das K, Tuske S, Birktoft JJ, Ilankumaran P, Ramesha AR, Sayer JM, Jerina DM, Boyer PL, Hughes SH, Arnold E.

EMBO J. 2002 Dec 2;21(23):6614-24.


Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.

Rausch JW, Lener D, Miller JT, Julias JG, Hughes SH, Le Grice SF.

Biochemistry. 2002 Apr 16;41(15):4856-65.


Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.

Boyer PL, Sarafianos SG, Arnold E, Hughes SH.

J Virol. 2001 May;75(10):4832-42.


Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

Sarafianos SG, Das K, Tantillo C, Clark AD Jr, Ding J, Whitcomb JM, Boyer PL, Hughes SH, Arnold E.

EMBO J. 2001 Mar 15;20(6):1449-61.


Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

Sluis-Cremer N, Arion D, Parniak MA.

Cell Mol Life Sci. 2000 Sep;57(10):1408-22. Review.


Initiation of minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.

Vaccaro JA, Singh HA, Anderson KS.

Biochemistry. 1999 Nov 30;38(48):15978-85.


Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.

Sarafianos SG, Das K, Clark AD Jr, Ding J, Boyer PL, Hughes SH, Arnold E.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32.


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