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Items: 1 to 20 of 55

1.

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.

De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL.

J Biol Chem. 2007 Apr 13;282(15):11590-601. Epub 2007 Feb 16.

2.

Monoclonal antibodies that target pathological assemblies of Abeta.

Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL.

J Neurochem. 2007 Jan;100(1):23-35. Epub 2006 Nov 20.

3.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076
4.

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42.

Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA.

J Neurochem. 2006 Feb;96(4):917-23. Epub 2006 Jan 12.

5.

A dynamic relationship between intracellular and extracellular pools of Abeta.

Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM.

Am J Pathol. 2006 Jan;168(1):184-94.

6.

Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjects.

Maccioni RB, Lavados M, Guillón M, Mujica C, Bosch R, Farías G, Fuentes P.

Neurobiol Aging. 2006 Feb;27(2):237-44. Epub 2005 Apr 7.

PMID:
16399209
7.

Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM.

J Neurosci Res. 2006 Feb 15;83(3):374-84.

PMID:
16385556
8.

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.

Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM.

J Biol Chem. 2006 Jan 20;281(3):1599-604. Epub 2005 Nov 10.

9.

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound.

Wasilewska-Sampaio AP, Silveira MS, Holub O, Goecking R, Gomes FC, Neto VM, Linden R, Ferreira ST, De Felice FG.

FASEB J. 2005 Oct;19(12):1627-36.

PMID:
16195371
10.
11.

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.

Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C.

J Neurochem. 2005 Apr;93(1):105-17.

12.

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL.

J Neurosci. 2004 Nov 10;24(45):10191-200.

13.

Deciphering the molecular basis of memory failure in Alzheimer's disease.

Walsh DM, Selkoe DJ.

Neuron. 2004 Sep 30;44(1):181-93. Review.

14.

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.

Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y.

J Biol Chem. 2004 Oct 22;279(43):44795-801. Epub 2004 Aug 20.

15.

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK.

EMBO J. 2004 Jul 7;23(13):2586-96. Epub 2004 Jun 10.

16.

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease.

Klein WL, Stine WB Jr, Teplow DB.

Neurobiol Aging. 2004 May-Jun;25(5):569-80. Review.

17.

Role of tau protein in both physiological and pathological conditions.

Avila J, Lucas JJ, Perez M, Hernandez F.

Physiol Rev. 2004 Apr;84(2):361-84. Review.

19.
20.

Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.

Hampel H, Buerger K, Zinkowski R, Teipel SJ, Goernitz A, Andreasen N, Sjoegren M, DeBernardis J, Kerkman D, Ishiguro K, Ohno H, Vanmechelen E, Vanderstichele H, McCulloch C, Moller HJ, Davies P, Blennow K.

Arch Gen Psychiatry. 2004 Jan;61(1):95-102.

PMID:
14706948

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