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Items: 1 to 20 of 24


Human laminopathies: nuclei gone genetically awry.

Capell BC, Collins FS.

Nat Rev Genet. 2006 Dec;7(12):940-52. Review.


Lamin A-dependent nuclear defects in human aging.

Scaffidi P, Misteli T.

Science. 2006 May 19;312(5776):1059-63. Epub 2006 Apr 27.


Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.

McClintock D, Gordon LB, Djabali K.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.


Chromosome alignment and segregation regulated by ubiquitination of survivin.

Vong QP, Cao K, Li HY, Iglesias PA, Zheng Y.

Science. 2005 Dec 2;310(5753):1499-504.


Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.

Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G.

Cell Mol Life Sci. 2005 Nov;62(22):2669-78.


Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29.


Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6. Epub 2005 Jul 12.


The nuclear lamina comes of age.

Gruenbaum Y, Margalit A, Goldman RD, Shumaker DK, Wilson KL.

Nat Rev Mol Cell Biol. 2005 Jan;6(1):21-31. Review.


Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.

Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8963-8. Epub 2004 Jun 7.


Lamin-dependent nuclear envelope reassembly following mitosis: an argument.

Lourim D, Krohne G.

Trends Cell Biol. 1994 Sep;4(9):314-8.


Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.

Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.

Nature. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.


Lamin a truncation in Hutchinson-Gilford progeria.

De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M, Lévy N.

Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17. No abstract available.


Nuclear lamins: building blocks of nuclear architecture.

Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP.

Genes Dev. 2002 Mar 1;16(5):533-47. Review. No abstract available.


Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes.

Liu J, Rolef Ben-Shahar T, Riemer D, Treinin M, Spann P, Weber K, Fire A, Gruenbaum Y.

Mol Biol Cell. 2000 Nov;11(11):3937-47.


Mitotic misregulation and human aging.

Ly DH, Lockhart DJ, Lerner RA, Schultz PG.

Science. 2000 Mar 31;287(5462):2486-92.


Sorting nuclear membrane proteins at mitosis.

Collas P, Courvalin JC.

Trends Cell Biol. 2000 Jan;10(1):5-8.


Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins.

Broers JL, Machiels BM, van Eys GJ, Kuijpers HJ, Manders EM, van Driel R, Ramaekers FC.

J Cell Sci. 1999 Oct;112 ( Pt 20):3463-75.


The processing pathway of prelamin A.

Sinensky M, Fantle K, Trujillo M, McLain T, Kupfer A, Dalton M.

J Cell Sci. 1994 Jan;107 ( Pt 1):61-7.

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