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Items: 1 to 20 of 51

1.

Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine.

Divi RL, Haverkos KJ, Humsi JA, Shockley ME, Thamire C, Nagashima K, Olivero OA, Poirier MC.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89.

PMID:
16894629
2.

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.

Longley MJ, Clark S, Yu Wai Man C, Hudson G, Durham SE, Taylor RW, Nightingale S, Turnbull DM, Copeland WC, Chinnery PF.

Am J Hum Genet. 2006 Jun;78(6):1026-34. Epub 2006 May 4.

3.

Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene.

Horvath R, Hudson G, Ferrari G, F├╝tterer N, Ahola S, Lamantea E, Prokisch H, Lochm├╝ller H, McFarland R, Ramesh V, Klopstock T, Freisinger P, Salvi F, Mayr JA, Santer R, Tesarova M, Zeman J, Udd B, Taylor RW, Turnbull D, Hanna M, Fialho D, Suomalainen A, Zeviani M, Chinnery PF.

Brain. 2006 Jul;129(Pt 7):1674-84. Epub 2006 Apr 18.

4.

Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma.

Pagnamenta AT, Taanman JW, Wilson CJ, Anderson NE, Marotta R, Duncan AJ, Bitner-Glindzicz M, Taylor RW, Laskowski A, Thorburn DR, Rahman S.

Hum Reprod. 2006 Oct;21(10):2467-73. Epub 2006 Apr 4.

5.

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

Lewis W, Kohler JJ, Hosseini SH, Haase CP, Copeland WC, Bienstock RJ, Ludaway T, McNaught J, Russ R, Stuart T, Santoianni R.

AIDS. 2006 Mar 21;20(5):675-84.

6.

DNA polymerase gamma in mitochondrial DNA replication and repair.

Graziewicz MA, Longley MJ, Copeland WC.

Chem Rev. 2006 Feb;106(2):383-405. Review. No abstract available.

PMID:
16464011
7.

The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations.

Loeb LA, Wallace DC, Martin GM.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. Epub 2005 Dec 19. No abstract available.

9.

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.

Longley DB, Wilson TR, McEwan M, Allen WL, McDermott U, Galligan L, Johnston PG.

Oncogene. 2006 Feb 9;25(6):838-48.

PMID:
16247474
10.

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

Chan SS, Longley MJ, Naviaux RK, Copeland WC.

DNA Repair (Amst). 2005 Dec 8;4(12):1381-9. Epub 2005 Sep 21.

PMID:
16181814
11.

Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy.

Lewis W.

Antivir Ther. 2005;10 Suppl 2:M13-27. Review.

PMID:
16152703
12.

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.

Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA.

Science. 2005 Jul 15;309(5733):481-4.

13.

Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

Lewis W, Haase CP, Miller YK, Ferguson B, Stuart T, Ludaway T, McNaught J, Russ R, Steltzer J, Santoianni R, Long R, Fiermonte G, Palmieri F.

Lab Invest. 2005 Aug;85(8):972-81.

14.

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.

Zhang D, Mott JL, Chang SW, Stevens M, Mikolajczak P, Zassenhaus HP.

Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2476-83.

15.

Gene expression profile in dilated cardiomyopathy caused by elevated frequencies of mitochondrial DNA mutations in the mouse heart.

Zhang D, Ezekiel UR, Chang SW, Zassenhaus HP.

Cardiovasc Pathol. 2005 Mar-Apr;14(2):61-9.

PMID:
15780797
16.

HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure.

Lewis W, Miller YK, Haase CP, Ludaway T, McNaught J, Russ R, Steltzer J, Folpe A, Long R, Oshinski J.

Lab Invest. 2005 Feb;85(2):182-92.

17.

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L, Majamaa K, Somer H, Suomalainen A.

Lancet. 2004 Sep 4-10;364(9437):875-82.

PMID:
15351195
18.

Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine.

Velsor LW, Kovacevic M, Goldstein M, Leitner HM, Lewis W, Day BJ.

Toxicol Appl Pharmacol. 2004 Aug 15;199(1):10-9.

PMID:
15289086
19.

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia.

Graziewicz MA, Longley MJ, Bienstock RJ, Zeviani M, Copeland WC.

Nat Struct Mol Biol. 2004 Aug;11(8):770-6. Epub 2004 Jul 18.

PMID:
15258572
20.

DNA polymerase gamma, the mitochondrial replicase.

Kaguni LS.

Annu Rev Biochem. 2004;73:293-320. Review.

PMID:
15189144
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