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Items: 1 to 20 of 33

1.

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.

Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA.

J Biol Chem. 2005 Apr 29;280(17):16916-24. Epub 2005 Feb 8.

2.

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P.

Cancer Res. 2005 Jan 15;65(2):613-21.

3.

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors.

Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, Rhee SG.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16419-24. Epub 2004 Nov 8.

4.

Why do cancers have high aerobic glycolysis?

Gatenby RA, Gillies RJ.

Nat Rev Cancer. 2004 Nov;4(11):891-9. Review.

PMID:
15516961
5.

PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment.

Zauli G, Sancilio S, Cataldi A, Sabatini N, Bosco D, Di Pietro R.

J Cell Physiol. 2005 Mar;202(3):900-11.

PMID:
15389633
6.

Nuclear factor-kappaB: the enemy within.

Aggarwal BB.

Cancer Cell. 2004 Sep;6(3):203-8. Review.

7.

PI 3-kinase, Akt and cell survival.

Downward J.

Semin Cell Dev Biol. 2004 Apr;15(2):177-82. Review.

PMID:
15209377
8.

Akt stimulates aerobic glycolysis in cancer cells.

Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, Thompson CB.

Cancer Res. 2004 Jun 1;64(11):3892-9.

9.

Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities.

Chan SL, Yu VC.

Clin Exp Pharmacol Physiol. 2004 Mar;31(3):119-28. Review.

PMID:
15008953
10.

Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.

Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB.

Mol Cell Biol. 2003 Oct;23(20):7315-28.

11.

On the origin of cancer cells.

WARBURG O.

Science. 1956 Feb 24;123(3191):309-14. No abstract available.

PMID:
13298683
12.

T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation.

Kwon J, Devadas S, Williams MS.

Free Radic Biol Med. 2003 Aug 15;35(4):406-17.

PMID:
12899942
13.

Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications.

Carew JS, Zhou Y, Albitar M, Carew JD, Keating MJ, Huang P.

Leukemia. 2003 Aug;17(8):1437-47.

PMID:
12886229
14.

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism.

Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, Huang P.

J Biol Chem. 2003 Sep 26;278(39):37832-9. Epub 2003 Jul 9.

15.

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

Kozikowski AP, Sun H, Brognard J, Dennis PA.

J Am Chem Soc. 2003 Feb 5;125(5):1144-5.

PMID:
12553797
16.

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.

Edinger AL, Thompson CB.

Mol Biol Cell. 2002 Jul;13(7):2276-88.

17.

Mitochondrial DNA alterations in cancer.

Copeland WC, Wachsman JT, Johnson FM, Penta JS.

Cancer Invest. 2002;20(4):557-69. Review.

PMID:
12094550
18.

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

Vivanco I, Sawyers CL.

Nat Rev Cancer. 2002 Jul;2(7):489-501. Review. No abstract available.

PMID:
12094235
19.

The phosphoinositide 3-kinase pathway.

Cantley LC.

Science. 2002 May 31;296(5573):1655-7. Review.

PMID:
12040186
20.

Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma.

Simonnet H, Alazard N, Pfeiffer K, Gallou C, Béroud C, Demont J, Bouvier R, Schägger H, Godinot C.

Carcinogenesis. 2002 May;23(5):759-68.

PMID:
12016148

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