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Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.

Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Høiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG.

Mol Cell Biol. 2006 Apr;26(7):2728-35.


The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.

Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33. Epub 2005 Sep 16.


Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG.

Cell. 2005 Jun 17;121(6):873-85.


WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD.

Cell. 2005 Jun 17;121(6):859-72.


MLL: how complex does it get?

Popovic R, Zeleznik-Le NJ.

J Cell Biochem. 2005 May 15;95(2):234-42. Review.


Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54. Epub 2005 Jan 7.


Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins.

Ringrose L, Paro R.

Annu Rev Genet. 2004;38:413-43. Review.


The molecular basis of leukemia.

Gilliland DG, Jordan CT, Felix CA.

Hematology Am Soc Hematol Educ Program. 2004:80-97. Review.


Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

Matheu A, Pantoja C, Efeyan A, Criado LM, Martín-Caballero J, Flores JM, Klatt P, Serrano M.

Genes Dev. 2004 Nov 15;18(22):2736-46. Epub 2004 Nov 1.


Hitting their targets: an emerging picture of E2F and cell cycle control.

Blais A, Dynlacht BD.

Curr Opin Genet Dev. 2004 Oct;14(5):527-32. Review.


Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.

Muyrers-Chen I, Rozovskaia T, Lee N, Kersey JH, Nakamura T, Canaani E, Paro R.

Oncogene. 2004 Nov 11;23(53):8639-48.


E2F target genes: unraveling the biology.

Bracken AP, Ciro M, Cocito A, Helin K.

Trends Biochem Sci. 2004 Aug;29(8):409-17. Review.


Mouse development and cell proliferation in the absence of D-cyclins.

Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P.

Cell. 2004 Aug 20;118(4):477-91.


Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

Høiby T, Mitsiou DJ, Zhou H, Erdjument-Bromage H, Tempst P, Stunnenberg HG.

EMBO J. 2004 Aug 4;23(15):3083-91. Epub 2004 Jul 15.


Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML.

Mol Cell Biol. 2004 Jul;24(13):5639-49.


Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis.

Daser A, Rabbitts TH.

Genes Dev. 2004 May 1;18(9):965-74. Review. No abstract available.


Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M.

Mol Cell. 2004 Feb 27;13(4):587-97.


ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.

Canaani E, Nakamura T, Rozovskaia T, Smith ST, Mori T, Croce CM, Mazo A.

Br J Cancer. 2004 Feb 23;90(4):756-60. Review.


Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.

Hsieh JJ, Cheng EH, Korsmeyer SJ.

Cell. 2003 Oct 31;115(3):293-303.

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