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Items: 1 to 20 of 57

1.

PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.

Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S.

Science. 2005 Apr 1;308(5718):114-8.

3.

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.

Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, Taskén K.

J Immunol. 2004 Oct 15;173(8):4847-58.

4.

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM.

EMBO J. 2004 Oct 13;23(20):3918-28. Epub 2004 Sep 30.

5.

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.

McManus EJ, Collins BJ, Ashby PR, Prescott AR, Murray-Tait V, Armit LJ, Arthur JS, Alessi DR.

EMBO J. 2004 May 19;23(10):2071-82. Epub 2004 Apr 29.

6.
7.

Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells.

Tokoyoda K, Tsujikawa K, Matsushita H, Ono Y, Hayashi T, Harada Y, Abe R, Kubo M, Yamamoto H.

Int Immunol. 2004 May;16(5):643-53. Epub 2004 Apr 5.

PMID:
15096485
8.

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.

Hinton HJ, Alessi DR, Cantrell DA.

Nat Immunol. 2004 May;5(5):539-45. Epub 2004 Apr 11.

PMID:
15077109
9.

Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.

Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK.

Nat Immunol. 2004 Apr;5(4):435-42. Epub 2004 Mar 7.

PMID:
15004555
10.

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.

Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR.

EMBO J. 2003 Aug 15;22(16):4202-11.

11.

Th1/Th2 profile in peripheral blood in atopic cough and atopic asthma.

Shirai T, Suzuki K, Inui N, Suda T, Chida K, Nakamura H.

Clin Exp Allergy. 2003 Jan;33(1):84-9.

PMID:
12534554
12.

Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.

Moore MJ, Kanter JR, Jones KC, Taylor SS.

J Biol Chem. 2002 Dec 6;277(49):47878-84. Epub 2002 Oct 7.

13.

Molecular mechanisms controlling the localisation of protein kinase A.

Griffioen G, Thevelein JM.

Curr Genet. 2002 Jul;41(4):199-207. Epub 2002 Jun 27. Review.

PMID:
12172960
14.

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM.

EMBO J. 2002 Aug 15;21(16):4219-28.

16.

Essential role of PDK1 in regulating cell size and development in mice.

Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR.

EMBO J. 2002 Jul 15;21(14):3728-38.

17.
18.

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells.

Rengarajan J, Tang B, Glimcher LH.

Nat Immunol. 2002 Jan;3(1):48-54. Epub 2001 Dec 10.

PMID:
11740499
19.

Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase.

Ørstavik S, Reinton N, Frengen E, Langeland BT, Jahnsen T, Skålhegg BS.

Eur J Biochem. 2001 Oct;268(19):5066-73.

20.

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR.

EMBO J. 2001 Aug 15;20(16):4380-90.

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