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Items: 1 to 20 of 158


Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. Epub 2005 Dec 12.


Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Epub 2005 Dec 12.


Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.

Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW.

J Biol Chem. 2006 Feb 3;281(5):2683-92. Epub 2005 Nov 17.


Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, Galietta LJ, Verkman AS.

J Clin Invest. 2005 Sep;115(9):2564-71. Epub 2005 Aug 25.


Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms.

Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH.

J Biol Chem. 2005 Oct 7;280(40):34288-95. Epub 2005 Aug 1.


Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A.

J Biol Chem. 2005 Aug 19;280(33):29765-70. Epub 2005 Jun 13.


Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.

Martinez M, Brice A, Vaughan JR, Zimprich A, Breteler MM, Meco G, Filla A, Farrer MJ, Bétard C, Singleton A, Hardy J, De Michele G, Bonifati V, Oostra BA, Gasser T, Wood NW, Dürr A.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):72-4.


ApoE isoform affects LTP in human targeted replacement mice.

Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, Sotak M, Sullivan PM, Pasternak JF, LaDu MJ.

Neuroreport. 2004 Dec 3;15(17):2655-8.


Six-month recovery from mild to moderate Traumatic Brain Injury: the role of APOE-epsilon4 allele.

Chamelian L, Reis M, Feinstein A.

Brain. 2004 Dec;127(Pt 12):2621-8. Epub 2004 Oct 20.


Mitochondrial stop and go: signals that regulate organelle movement.

Reynolds IJ, Rintoul GL.

Sci STKE. 2004 Sep 21;2004(251):PE46. Review.


APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study.

Gottlieb DJ, DeStefano AL, Foley DJ, Mignot E, Redline S, Givelber RJ, Young T.

Neurology. 2004 Aug 24;63(4):664-8.


Emerging classes of protein-protein interaction inhibitors and new tools for their development.

Pagliaro L, Felding J, Audouze K, Nielsen SJ, Terry RB, Krog-Jensen C, Butcher S.

Curr Opin Chem Biol. 2004 Aug;8(4):442-9. Review.


Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif.

Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M.

J Virol. 2004 Aug;78(15):7958-68.


Apolipoprotein E controls the risk and age at onset of Parkinson disease.

Li YJ, Hauser MA, Scott WK, Martin ER, Booze MW, Qin XJ, Walter JW, Nance MA, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Small GW, Mastaglia F, Haines JL, Pericak-Vance MA, Vance JM.

Neurology. 2004 Jun 8;62(11):2005-9.


Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

Huang Y, Weisgraber KH, Mucke L, Mahley RW.

J Mol Neurosci. 2004;23(3):189-204. Review.


Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y.

J Biol Chem. 2004 Jun 11;279(24):25511-6. Epub 2004 Mar 30.


Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

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