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Items: 1 to 20 of 36


Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. Epub 2006 Jan 31.


Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.

Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, Tschäpe JA, De Strooper B, Müller U, Shen J, Hartmann T.

Nat Cell Biol. 2005 Nov;7(11):1118-23. Erratum in: Nat Cell Biol. 2006 Apr;8(4):424.


Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1.

Huang P, Altshuller YM, Hou JC, Pessin JE, Frohman MA.

Mol Biol Cell. 2005 Jun;16(6):2614-23. Epub 2005 Mar 16.


Purification and characterization of the human gamma-secretase complex.

Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Aug 3;43(30):9774-89.


Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.

Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H.

J Biol Chem. 2004 Sep 24;279(39):40560-6. Epub 2004 Jul 7.


Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.

Du G, Huang P, Liang BT, Frohman MA.

Mol Biol Cell. 2004 Mar;15(3):1024-30. Epub 2004 Jan 12.


Reconstitution of gamma-secretase activity.

Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C.

Nat Cell Biol. 2003 May;5(5):486-8.


A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.

Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G.

Neurobiol Dis. 2002 Oct;11(1):64-82.


Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.

Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H.

J Biol Chem. 2003 Jan 31;278(5):3446-54. Epub 2002 Nov 14.


aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D.

Dev Cell. 2002 Jul;3(1):85-97.


A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C.

EMBO Rep. 2002 Jul;3(7):688-94.


gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Sisodia SS, St George-Hyslop PH.

Nat Rev Neurosci. 2002 Apr;3(4):281-90. Review. No abstract available.


Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.

Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G.

J Biol Chem. 2002 May 24;277(21):19236-40. Epub 2002 Apr 9.


Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.

Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H.

J Biol Chem. 2002 Apr 5;277(14):12128-36. Epub 2002 Jan 31.


APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.

Goutte C, Tsunozaki M, Hale VA, Priess JR.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):775-9. Epub 2002 Jan 15.


Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.

Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B.

Neuron. 2001 Nov 20;32(4):579-89.


Intracellular localization of phospholipase D1 in mammalian cells.

Freyberg Z, Sweeney D, Siddhanta A, Bourgoin S, Frohman M, Shields D.

Mol Biol Cell. 2001 Apr;12(4):943-55.


Lack of requirement for presenilin1 in Notch1 signaling.

Berechid BE, Thinakaran G, Wong PC, Sisodia SS, Nye JS.

Curr Biol. 1999 Dec 16-30;9(24):1493-6.


Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM.

J Biol Chem. 1999 Dec 17;274(51):36801-7.


Alzheimer's disease. A firm base for drug development.

De Strooper B, König G.

Nature. 1999 Dec 2;402(6761):471-2. No abstract available.


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