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Items: 1 to 20 of 74

1.

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A, Alessi DR.

EMBO J. 2005 May 18;24(10):1810-20. Epub 2005 May 5.

2.

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.

Long X, Ortiz-Vega S, Lin Y, Avruch J.

J Biol Chem. 2005 Jun 24;280(25):23433-6. Epub 2005 May 5.

3.

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.

4.

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

Ali SM, Sabatini DM.

J Biol Chem. 2005 May 20;280(20):19445-8. Epub 2005 Apr 4.

5.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

6.

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.

Endocrinology. 2005 Mar;146(3):1328-37. Epub 2004 Dec 2.

PMID:
15576463
7.

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN.

Nat Cell Biol. 2004 Nov;6(11):1122-8. Epub 2004 Oct 3.

PMID:
15467718
9.

SKAR is a specific target of S6 kinase 1 in cell growth control.

Richardson CJ, Bröenstrup M, Fingar DC, Jülich K, Ballif BA, Gygi S, Blenis J.

Curr Biol. 2004 Sep 7;14(17):1540-9.

10.
11.

Upstream and downstream of mTOR.

Hay N, Sonenberg N.

Genes Dev. 2004 Aug 15;18(16):1926-45. Review.

12.

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.

Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G.

Nature. 2004 Sep 9;431(7005):200-5. Epub 2004 Aug 11. Erratum in: Nature. 2004 Sep 23;431(7007):485.

PMID:
15306821
13.

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Curr Biol. 2004 Jul 27;14(14):1296-302.

14.

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC.

Cancer Cell. 2004 Jul;6(1):91-9.

15.

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.

16.

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL.

Genes Dev. 2004 Jul 1;18(13):1533-8.

17.

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

Werner ED, Lee J, Hansen L, Yuan M, Shoelson SE.

J Biol Chem. 2004 Aug 20;279(34):35298-305. Epub 2004 Jun 14.

18.

In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites.

Sommerfeld MR, Metzger S, Stosik M, Tennagels N, Eckel J.

Biochemistry. 2004 May 18;43(19):5888-901.

PMID:
15134463
19.

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.

Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K.

Genes Cells. 2004 Apr;9(4):359-66. Erratum in: Genes Cells. 2004 May;9(5):497.

20.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.

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