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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT.

Cell Metab. 2005 Jun;1(6):401-8.


Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.

Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC.

Cell Metab. 2005 Jun;1(6):393-9.


The role of the unfolded protein response in tumour development: friend or foe?

Ma Y, Hendershot LM.

Nat Rev Cancer. 2004 Dec;4(12):966-77. Review.


XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC.

Cancer Res. 2004 Sep 1;64(17):5943-7.


Activating transcription factor 4 is translationally regulated by hypoxic stress.

Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC.

Mol Cell Biol. 2004 Sep;24(17):7469-82.


Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.

Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP.

EMBO J. 2004 Jan 14;23(1):169-79. Epub 2004 Jan 8.


Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.

Ameri K, Lewis CE, Raida M, Sowter H, Hai T, Harris AL.

Blood. 2004 Mar 1;103(5):1876-82. Epub 2003 Nov 6.


Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA.

Mol Cell Biol. 2003 Oct;23(20):7198-209.


The hypoxic response of tumors is dependent on their microenvironment.

Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G.

Cancer Cell. 2003 Aug;4(2):133-46.


Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.

Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB.

J Cell Biol. 2003 Jul 7;162(1):59-69.


An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D.

Mol Cell. 2003 Mar;11(3):619-33.


BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.

Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ.

Science. 2003 Apr 4;300(5616):135-9. Epub 2003 Mar 6.


ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.

Hammond EM, Dorie MJ, Giaccia AJ.

J Biol Chem. 2003 Apr 4;278(14):12207-13. Epub 2003 Jan 7.


Orchestrating the unfolded protein response in health and disease.

Kaufman RJ.

J Clin Invest. 2002 Nov;110(10):1389-98. Review. No abstract available.


Translational control in the endoplasmic reticulum stress response.

Ron D.

J Clin Invest. 2002 Nov;110(10):1383-8. Review. No abstract available.


Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG.

Mol Cell Biol. 2002 Nov;22(21):7405-16.


The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.

Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR.

Mol Cell Biol. 2002 Jun;22(11):3864-74.


Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation.

Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE.

J Biol Chem. 2001 Sep 7;276(36):33869-74. Epub 2001 Jul 11.

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