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Properties of WNK1 and implications for other family members.

Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26653-8.


WNK kinases and the control of blood pressure.

Cope G, Golbang A, O'Shaughnessy KM.

Pharmacol Ther. 2005 May;106(2):221-31. Review.


Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.

Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH.

J Clin Invest. 2005 May;115(5):1379-87.


Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch.

Kahle KT, Wilson FH, Lifton RP.

Trends Endocrinol Metab. 2005 Apr;16(3):98-103. Review.


WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.

Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH.

Mol Cell. 2004 Sep 10;15(5):741-51.


Regulation of protein kinases; controlling activity through activation segment conformation.

Nolen B, Taylor S, Ghosh G.

Mol Cell. 2004 Sep 10;15(5):661-75. Review.


Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.

Kamide K, Takiuchi S, Tanaka C, Miwa Y, Yoshii M, Horio T, Mannami T, Kokubo Y, Tomoike H, Kawano Y, Miyata T.

Am J Hypertens. 2004 May;17(5 Pt 1):446-9.


Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.

Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4690-4.


WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR.

Biochem J. 2004 Feb 15;378(Pt 1):257-68.


Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14.


WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.

Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP.

Nat Genet. 2003 Dec;35(4):372-6.


MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.

EMBO J. 2003 Oct 1;22(19):5102-14.


Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.

EMBO J. 2003 Jun 16;22(12):3062-72.


Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, J├Ąger D, Chen YT, Mackay A, O'Hare MJ, Old LJ.

Cancer Immun. 2001 Mar 30;1:4.


WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.

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