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Genetic basis of pulmonary arterial hypertension: current understanding and future directions.

Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA 3rd, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G.

J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):33S-39S. Review.


Clinical classification of pulmonary hypertension.

Simonneau G, Galiè N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A.

J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):5S-12S. Review.


Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle.

West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, Hoedt-Miller M, Tada Y, Ozimek J, Tuder R, Rodman DM.

Circ Res. 2004 Apr 30;94(8):1109-14. Epub 2004 Mar 18.


Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.

Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY.

Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1775-84. Epub 2004 Jan 15.


Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta.

Cogolludo A, Moreno L, Bosca L, Tamargo J, Perez-Vizcaino F.

Circ Res. 2003 Oct 3;93(7):656-63. Epub 2003 Sep 11.


Inflammation in pulmonary arterial hypertension.

Dorfmüller P, Perros F, Balabanian K, Humbert M.

Eur Respir J. 2003 Aug;22(2):358-63. Review.


Primary pulmonary hypertension.

Runo JR, Loyd JE.

Lancet. 2003 May 3;361(9368):1533-44. Review.


Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension.

Jeffery TK, Morrell NW.

Prog Cardiovasc Dis. 2002 Nov-Dec;45(3):173-202. Review.


Consequences of knocking out BMP signaling in the mouse.

Zhao GQ.

Genesis. 2003 Jan;35(1):43-56. Review.


Expression of 5-lipoxygenase in pulmonary artery endothelial cells.

Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J.

Biochem J. 2002 Jan 15;361(Pt 2):267-76.


BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.

Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, Phillips JA 3rd, Newman J, Williams D, Galiè N, Manes A, McNeil K, Yacoub M, Mikhail G, Rogers P, Corris P, Humbert M, Donnai D, Martensson G, Tranebjaerg L, Loyd JE, Trembath RC, Nichols WC.

Am J Hum Genet. 2001 Jan;68(1):92-102. Epub 2000 Dec 12.


Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.

Thomson JR, Machado RD, Pauciulo MW, Morgan NV, Humbert M, Elliott GC, Ward K, Yacoub M, Mikhail G, Rogers P, Newman J, Wheeler L, Higenbottam T, Gibbs JS, Egan J, Crozier A, Peacock A, Allcock R, Corris P, Loyd JE, Trembath RC, Nichols WC.

J Med Genet. 2000 Oct;37(10):741-5.


Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension.

International PPH Consortium, Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA 3rd, Loyd JE, Nichols WC, Trembath RC.

Nat Genet. 2000 Sep;26(1):81-4.


Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.

Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA.

Am J Hum Genet. 2000 Sep;67(3):737-44. Epub 2000 Jul 20.


BMP type II receptor is required for gastrulation and early development of mouse embryos.

Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K.

Dev Biol. 2000 May 1;221(1):249-58.


In situ localization and regulation of thromboxane A(2) synthase in normal and LPS-primed lungs.

Ermert L, Ermert M, Duncker HR, Grimminger F, Seeger W.

Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L744-53.


Primary pulmonary hypertension.

Peacock AJ.

Thorax. 1999 Dec;54(12):1107-18. Review. No abstract available. Erratum in: Thorax 2000 Mar;55(3):254.


Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2.

Brock TG, McNish RW, Peters-Golden M.

J Biol Chem. 1999 Apr 23;274(17):11660-6.


Primary pulmonary hypertension between inflammation and cancer.

Voelkel NF, Cool C, Lee SD, Wright L, Geraci MW, Tuder RM.

Chest. 1998 Sep;114(3 Suppl):225S-230S. Review.


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