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Items: 1 to 20 of 61

1.

The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.

Dai C, Lyustikman Y, Shih A, Hu X, Fuller GN, Rosenblum M, Holland EC.

Neoplasia. 2005 Apr;7(4):397-406.

2.

The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.

Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH.

J Neuropathol Exp Neurol. 2004 May;63(5):499-509.

PMID:
15198128
3.

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.

Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR.

Nat Med. 2004 Jun;10(6):594-601. Epub 2004 May 23.

PMID:
15156201
4.

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.

Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW.

Nature. 2004 Mar 18;428(6980):332-7.

5.

Pten dose dictates cancer progression in the prostate.

Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van Dyke T, Cordon-Cardo C, Pandolfi PP.

PLoS Biol. 2003 Dec;1(3):E59. Epub 2003 Oct 27.

6.

Cancerous stem cells can arise from pediatric brain tumors.

Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83. Epub 2003 Nov 26.

7.

Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.

Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC.

Mol Cell. 2003 Oct;12(4):889-901.

8.

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.

Kwon CH, Zhu X, Zhang J, Baker SJ.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12923-8. Epub 2003 Oct 8.

9.

Identification of a cancer stem cell in human brain tumors.

Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB.

Cancer Res. 2003 Sep 15;63(18):5821-8.

10.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.

11.

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.

Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS.

Cancer Res. 2003 Jun 1;63(11):2742-6.

12.

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.

Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H.

Cancer Cell. 2003 Feb;3(2):117-30.

13.

MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.

Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC.

Neoplasia. 2002 Nov-Dec;4(6):480-5.

14.
15.

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro.

Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA.

Glia. 2002 Sep;39(3):193-206.

PMID:
12203386
16.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553
17.

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

Vivanco I, Sawyers CL.

Nat Rev Cancer. 2002 Jul;2(7):489-501. Review. No abstract available.

PMID:
12094235
18.

Pten signaling in gliomas.

Knobbe CB, Merlo A, Reifenberger G.

Neuro Oncol. 2002 Jul;4(3):196-211. Review.

19.

Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic.

Castedo M, Ferri KF, Kroemer G.

Cell Death Differ. 2002 Feb;9(2):99-100. No abstract available.

20.

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.

Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ.

Nat Genet. 2001 Dec;29(4):404-11.

PMID:
11726927

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