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Items: 1 to 20 of 31

1.

Dysregulation of the TSC-mTOR pathway in human disease.

Inoki K, Corradetti MN, Guan KL.

Nat Genet. 2005 Jan;37(1):19-24. Review.

PMID:
15624019
2.

The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.

Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB.

Science. 2004 Oct 22;306(5696):695-8.

3.

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN.

Nat Cell Biol. 2004 Nov;6(11):1122-8. Epub 2004 Oct 3.

PMID:
15467718
4.

Methods for monitoring autophagy.

Mizushima N.

Int J Biochem Cell Biol. 2004 Dec;36(12):2491-502. Review.

PMID:
15325587
5.

Regulation and role of autophagy in mammalian cells.

Meijer AJ, Codogno P.

Int J Biochem Cell Biol. 2004 Dec;36(12):2445-62. Review.

PMID:
15325584
6.

Upstream and downstream of mTOR.

Hay N, Sonenberg N.

Genes Dev. 2004 Aug 15;18(16):1926-45. Review.

7.

TOR signaling.

Harris TE, Lawrence JC Jr.

Sci STKE. 2003 Dec 9;2003(212):re15. Review.

PMID:
14668532
8.

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Yue Z, Jin S, Yang C, Levine AJ, Heintz N.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82. Epub 2003 Dec 1.

9.

TSC2 mediates cellular energy response to control cell growth and survival.

Inoki K, Zhu T, Guan KL.

Cell. 2003 Nov 26;115(5):577-90.

10.

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B.

J Clin Invest. 2003 Dec;112(12):1809-20. Epub 2003 Nov 24.

11.

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, Hannan RD.

Mol Cell Biol. 2003 Dec;23(23):8862-77.

12.

Targeting the PI3K-Akt pathway in human cancer: rationale and promise.

Luo J, Manning BD, Cantley LC.

Cancer Cell. 2003 Oct;4(4):257-62. Review. No abstract available.

13.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.

J Clin Invest. 2003 Oct;112(8):1223-33.

14.

Raptor and mTOR: subunits of a nutrient-sensitive complex.

Kim DH, Sabatini DM.

Curr Top Microbiol Immunol. 2004;279:259-70. Review.

PMID:
14560962
15.

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.

Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C.

Nat Genet. 2002 Nov;32(3):355-7. Epub 2002 Oct 15. Erratum in: Nat Genet 2002 Dec;32(4):681.

PMID:
12379854
16.
17.

The p53MH algorithm and its application in detecting p53-responsive genes.

Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8467-72. Epub 2002 Jun 19.

18.

The p53 functional circuit.

Jin S, Levine AJ.

J Cell Sci. 2001 Dec;114(Pt 23):4139-40. No abstract available.

19.

Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.

20.

Regulation of PTEN transcription by p53.

Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW.

Mol Cell. 2001 Aug;8(2):317-25.

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