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Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt.

Matsui T, Rosenzweig A.

J Mol Cell Cardiol. 2005 Jan;38(1):63-71. Epub 2004 Dec 13. Review.


Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.

Huang A, Zhang YY, Chen K, Hatakeyama K, Keaney JF Jr.

Circ Res. 2005 Feb 4;96(2):164-71. Epub 2004 Dec 16.


cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.

Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA.

Circ Res. 2005 Jan 7;96(1):100-9. Epub 2004 Dec 2.


Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?

Engberding N, Spiekermann S, Schaefer A, Heineke A, Wiencke A, Müller M, Fuchs M, Hilfiker-Kleiner D, Hornig B, Drexler H, Landmesser U.

Circulation. 2004 Oct 12;110(15):2175-9. Epub 2004 Oct 4.


Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox.

Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS.

Circulation. 2004 Mar 9;109(9):1168-71. Epub 2004 Feb 23.


Pressure-induced matrix metalloproteinase-9 contributes to early hypertensive remodeling.

Lehoux S, Lemarié CA, Esposito B, Lijnen HR, Tedgui A.

Circulation. 2004 Mar 2;109(8):1041-7. Epub 2004 Feb 16.


Cardiac remodeling in systemic hypertension.

Kenchaiah S, Pfeffer MA.

Med Clin North Am. 2004 Jan;88(1):115-30. Review.


Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.

Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y, Kass DA.

Circ Res. 2004 Mar 19;94(5):657-63. Epub 2004 Jan 29.


Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.

Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A.

Circulation. 2004 Feb 3;109(4):544-9. Epub 2004 Jan 26.


Single-sample preparation for simultaneous cellular redox and energy state determination.

Lazzarino G, Amorini AM, Fazzina G, Vagnozzi R, Signoretti S, Donzelli S, Di Stasio E, Giardina B, Tavazzi B.

Anal Biochem. 2003 Nov 1;322(1):51-9.


cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.

Shiraishi H, Kato T, Atsuta K, Sumi-Ichinose C, Ohtsuki M, Itoh M, Hishida H, Tada S, Udagawa Y, Nagatsu T, Hagino Y, Ichinose H, Nomura T.

J Pharmacol Sci. 2003 Nov;93(3):265-71.


Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency.

Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1070-5. Epub 2003 Nov 26.


Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy.

Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J.

J Clin Invest. 2003 Nov;112(9):1395-406.


Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases.

Takano H, Zou Y, Hasegawa H, Akazawa H, Nagai T, Komuro I.

Antioxid Redox Signal. 2003 Dec;5(6):789-94. Review.


Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.

Byrne JA, Grieve DJ, Bendall JK, Li JM, Gove C, Lambeth JD, Cave AC, Shah AM.

Circ Res. 2003 Oct 31;93(9):802-5. Epub 2003 Oct 9.


Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP.

EMBO J. 2003 Oct 15;22(20):5501-10.


Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM.

J Clin Invest. 2003 Sep;112(5):725-35.


Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival.

Matsui T, Nagoshi T, Rosenzweig A.

Cell Cycle. 2003 May-Jun;2(3):220-3. Review.


Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy.

Cappola TP, Cope L, Cernetich A, Barouch LA, Minhas K, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JG, Hare JM.

Physiol Genomics. 2003 Jun 24;14(1):25-34.


Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG.

J Clin Invest. 2003 Apr;111(8):1201-9.

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