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Long-lived Drosophila with overexpressed dFOXO in adult fat body.

Giannakou ME, Goss M, Jünger MA, Hafen E, Leevers SJ, Partridge L.

Science. 2004 Jul 16;305(5682):361. Epub 2004 Jun 10.


Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.

Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M.

Nature. 2004 Jun 3;429(6991):562-6. Erratum in: Nature. 2005 Mar 3;434(7029):118. Gersham, Boris [corrected to Gershman, Boris].


Redox-active metals, oxidative stress, and Alzheimer's disease pathology.

Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT.

Ann N Y Acad Sci. 2004 Mar;1012:153-63. Review.


Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.

Science. 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19.


Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.

Sponne I, Fifre A, Drouet B, Klein C, Koziel V, Pinçon-Raymond M, Olivier JL, Chambaz J, Pillot T.

J Biol Chem. 2003 Jan 31;278(5):3437-45. Epub 2002 Nov 14.


Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death.

Butterfield DA, Castegna A, Lauderback CM, Drake J.

Neurobiol Aging. 2002 Sep-Oct;23(5):655-64. Review.


Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI.

J Biol Chem. 2002 Oct 25;277(43):40302-8. Epub 2002 Aug 20.


Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis.

Wei W, Norton DD, Wang X, Kusiak JW.

Brain. 2002 Sep;125(Pt 9):2036-43.


Cell cycle and death control: long live Forkheads.

Burgering BM, Kops GJ.

Trends Biochem Sci. 2002 Jul;27(7):352-60. Review.


Cell death mechanisms in neurodegeneration.

Jellinger KA.

J Cell Mol Med. 2001 Jan-Mar;5(1):1-17. Review.


A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG.

Oncogene. 2002 May 30;21(24):3872-8.


DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.

Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang LW, Greenberg ME.

Science. 2002 Apr 19;296(5567):530-4.


FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling.

Zheng WH, Kar S, Quirion R.

J Neurochem. 2002 Mar;80(6):1049-61.


Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

Nemoto S, Finkel T.

Science. 2002 Mar 29;295(5564):2450-2. Epub 2002 Mar 7.


Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.

Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM.

Mol Cell Biol. 2002 Apr;22(7):2025-36.


Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection.

Wei W, Wang X, Kusiak JW.

J Biol Chem. 2002 May 17;277(20):17649-56. Epub 2002 Mar 6.


c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation.

Le S, Connors TJ, Maroney AC.

J Biol Chem. 2001 Dec 21;276(51):48332-6. Epub 2001 Oct 15.

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