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Items: 1 to 20 of 35


Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.

Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1442-7. Epub 2005 Jan 25.


Activation-dependent conformational changes in {beta}-arrestin 2.

Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ.

J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22.


Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.

Ahn S, Shenoy SK, Wei H, Lefkowitz RJ.

J Biol Chem. 2004 Aug 20;279(34):35518-25. Epub 2004 Jun 17.


beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8603-7. Epub 2004 Jun 1.


Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.

Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G.

Mol Cell. 2004 May 7;14(3):303-17.


Rational siRNA design for RNA interference.

Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A.

Nat Biotechnol. 2004 Mar;22(3):326-30. Epub 2004 Feb 1.


Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

Ahn S, Wei H, Garrison TR, Lefkowitz RJ.

J Biol Chem. 2004 Feb 27;279(9):7807-11. Epub 2004 Jan 7.


Non-visual GRKs: are we seeing the whole picture?

Willets JM, Challiss RA, Nahorski SR.

Trends Pharmacol Sci. 2003 Dec;24(12):626-33. Review.


Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors.

Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, PiƱeyro G.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11406-11. Epub 2003 Sep 17.


Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.

Martin NP, Lefkowitz RJ, Shenoy SK.

J Biol Chem. 2003 Nov 14;278(46):45954-9. Epub 2003 Sep 5.


Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10782-7. Epub 2003 Aug 29.


Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.

Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD, Torres GE, Kim KM, Lefkowitz RJ, Caron MG, Premont RT.

Neuron. 2003 Apr 24;38(2):291-303.


Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.

Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1740-4. Epub 2003 Feb 11.


Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.

Kohout TA, Lefkowitz RJ.

Mol Pharmacol. 2003 Jan;63(1):9-18. Review. No abstract available.


The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM.

J Biol Chem. 2003 Feb 21;278(8):6258-67. Epub 2002 Dec 6.


Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

Fong AM, Premont RT, Richardson RM, Yu YR, Lefkowitz RJ, Patel DD.

Proc Natl Acad Sci U S A. 2002 May 28;99(11):7478-83.


The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.

Luttrell LM, Lefkowitz RJ.

J Cell Sci. 2002 Feb 1;115(Pt 3):455-65. Review.


beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.

Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, Miller WE, Lefkowitz RJ, Olefsky JM.

J Biol Chem. 2001 Nov 23;276(47):43663-7. Epub 2001 Sep 6.

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