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Items: 1 to 20 of 40

1.

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. Epub 2004 Mar 15.

2.

Neuroscience. The fat-brain axis enters a new dimension.

Elmquist JK, Flier JS.

Science. 2004 Apr 2;304(5667):63-4. No abstract available.

PMID:
15064411
3.

The human MC4R promoter: characterization and role in obesity.

Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C.

Diabetes. 2003 Dec;52(12):2996-3000.

4.

Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells.

Van Sande J, Costa MJ, Massart C, Swillens S, Costagliola S, Orgiazzi J, Dumont JE.

J Clin Endocrinol Metab. 2003 Nov;88(11):5366-74.

PMID:
14602775
5.

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schäfer H, Gudermann T, Hebebrand J.

J Clin Endocrinol Metab. 2003 Sep;88(9):4258-67.

PMID:
12970296
6.

Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking.

Trejo J.

J Pharmacol Exp Ther. 2003 Nov;307(2):437-42. Epub 2003 Sep 9. Review.

7.

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.

Srinivasan S, Vaisse C, Conklin BR.

Ann N Y Acad Sci. 2003 Jun;994:225-32. Review.

PMID:
12851320
9.

Molecular genetics of human obesity-associated MC4R mutations.

Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C.

Ann N Y Acad Sci. 2003 Jun;994:49-57. Review.

PMID:
12851297
10.

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.

Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA.

J Biol Chem. 2003 Jun 20;278(25):22939-45. Epub 2003 Apr 9.

11.

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S.

N Engl J Med. 2003 Mar 20;348(12):1085-95.

12.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S.

Hum Mol Genet. 2003 Mar 1;12(5):561-74.

PMID:
12588803
13.

Is the energy homeostasis system inherently biased toward weight gain?

Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL.

Diabetes. 2003 Feb;52(2):232-8.

14.

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.

Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C.

Hum Mol Genet. 2003 Jan 15;12(2):145-53.

PMID:
12499395
15.

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.

Seifert R, Wenzel-Seifert K.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):381-416. Epub 2002 Sep 6. Review.

PMID:
12382069
16.

Genetic approaches to studying energy balance: perception and integration.

Barsh GS, Schwartz MW.

Nat Rev Genet. 2002 Aug;3(8):589-600. Review. No abstract available.

PMID:
12154382
17.

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH.

Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. Review. Corrected and republished in: Eur J Pharmacol. 2002 Aug 16;450(1):93-109.

PMID:
12007532
19.

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.

Govaerts C, Lefort A, Costagliola S, Wodak SJ, Ballesteros JA, Van Sande J, Pardo L, Vassart G.

J Biol Chem. 2001 Jun 22;276(25):22991-9. Epub 2001 Apr 18.

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