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PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ.

EMBO J. 2001 Oct 15;20(20):5692-702.


The essential role of MEKK3 in TNF-induced NF-kappaB activation.

Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B.

Nat Immunol. 2001 Jul;2(7):620-4.


Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.

Salmerón A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.

J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.


Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression.

Kovarik P, Mangold M, Ramsauer K, Heidari H, Steinborn R, Zotter A, Levy DE, Müller M, Decker T.

EMBO J. 2001 Jan 15;20(1-2):91-100.


TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.

Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN.

Cell. 2000 Dec 22;103(7):1071-83.


Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

Kim AH, Khursigara G, Sun X, Franke TF, Chao MV.

Mol Cell Biol. 2001 Feb;21(3):893-901.


T cell receptor signalling.

Lin J, Weiss A.

J Cell Sci. 2001 Jan;114(Pt 2):243-4. No abstract available.


Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.

Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A.

Nat Immunol. 2001 Jan;2(1):37-44.


Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation.

Tuosto L, Costanzo A, Guido F, Marinari B, Vossio S, Moretti F, Levrero M, Piccolella E.

Eur J Immunol. 2000 Sep;30(9):2445-54.


Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.


Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC.

J Biol Chem. 2000 Nov 17;275(46):36108-15.


Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase.

Yamada T, Mitani T, Yorita K, Uchida D, Matsushima A, Iwamasa K, Fujita S, Matsumoto M.

J Immunol. 2000 Jul 15;165(2):804-12.


Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo.

Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, Ohashi PS.

J Exp Med. 2000 May 15;191(10):1721-34.


Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.

Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5208-13.


Signal transduction by the TCR for antigen.

Kane LP, Lin J, Weiss A.

Curr Opin Immunol. 2000 Jun;12(3):242-9. Review.


Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.

Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML.

Mol Cell Biol. 2000 Apr;20(7):2556-68.


Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW.

Mol Cell Biol. 2000 Mar;20(5):1626-38.


Cellular survival: a play in three Akts.

Datta SR, Brunet A, Greenberg ME.

Genes Dev. 1999 Nov 15;13(22):2905-27. Review. No abstract available.

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