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Items: 1 to 20 of 36

1.

Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys.

Mihara M, Kotoh M, Nishimoto N, Oda Y, Kumagai E, Takagi N, Tsunemi K, Ohsugi Y, Kishimoto T, Yoshizaki K, Takeda Y.

Clin Immunol. 2001 Mar;98(3):319-26.

PMID:
11237555
2.

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation.

Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M, Yoshimura A.

J Exp Med. 2001 Feb 19;193(4):471-81.

3.

Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.

Kim SH, Evans CH, Kim S, Oligino T, Ghivizzani SC, Robbins PD.

Arthritis Res. 2000;2(4):293-302. Epub 2000 May 24.

4.

The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis.

Gerlag DM, Ransone L, Tak PP, Han Z, Palanki M, Barbosa MS, Boyle D, Manning AM, Firestein GS.

J Immunol. 2000 Aug 1;165(3):1652-8.

5.

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.

Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A.

J Biol Chem. 2000 Sep 22;275(38):29338-47.

6.

Negative regulation of cytokine signaling pathways.

Yasukawa H, Sasaki A, Yoshimura A.

Annu Rev Immunol. 2000;18:143-64. Review.

PMID:
10837055
7.

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.

Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, Silva A, Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6493-8.

8.

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.

Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F.

J Biol Chem. 2000 Apr 28;275(17):12848-56.

9.

Activation of the IL-4 STAT pathway in rheumatoid synovium.

Müller-Ladner U, Judex M, Ballhorn W, Kullmann F, Distler O, Schlottmann K, Gay RE, Schölmerich J, Gay S.

J Immunol. 2000 Apr 1;164(7):3894-901.

10.

Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis.

Boe A, Baiocchi M, Carbonatto M, Papoian R, Serlupi-Crescenzi O.

Cytokine. 1999 Dec;11(12):1057-64.

PMID:
10623431
11.

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

Bode JG, Nimmesgern A, Schmitz J, Schaper F, Schmitt M, Frisch W, Häussinger D, Heinrich PC, Graeve L.

FEBS Lett. 1999 Dec 17;463(3):365-70.

12.

Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A, Yoshimura A.

Blood. 1999 Oct 15;94(8):2880-9.

13.

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.

Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A.

Genes Cells. 1999 Jun;4(6):339-51.

14.

Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts.

Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Isshiki M, Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, Nakamura K, Tanaka S.

J Clin Invest. 1999 Jul;104(2):137-46.

15.

Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis.

Taniguchi K, Kohsaka H, Inoue N, Terada Y, Ito H, Hirokawa K, Miyasaka N.

Nat Med. 1999 Jul;5(7):760-7.

PMID:
10395320
16.
17.

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

Kamura T, Sato S, Haque D, Liu L, Kaelin WG Jr, Conaway RC, Conaway JW.

Genes Dev. 1998 Dec 15;12(24):3872-81.

18.

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody.

Yoshizaki K, Nishimoto N, Mihara M, Kishimoto T.

Springer Semin Immunopathol. 1998;20(1-2):247-59. Review. No abstract available.

PMID:
9836380
19.

Interleukin 6 plays a key role in the development of antigen-induced arthritis.

Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Nomura S, Kopf M, Katada Y, Tanaka T, Suemura M, Kishimoto T.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8222-6.

20.

Interleukin 6 is required for the development of collagen-induced arthritis.

Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, De Benedetti F, Poli V, Ciliberto G.

J Exp Med. 1998 Feb 16;187(4):461-8.

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