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Items: 1 to 20 of 28

1.

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 1999 Dec;14(6):419-27.

2.

Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.

Nature. 1999 Dec 2;402(6761):537-40.

PMID:
10591214
3.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
4.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

5.

Translating cell biology into therapeutic advances in Alzheimer's disease.

Selkoe DJ.

Nature. 1999 Jun 24;399(6738 Suppl):A23-31. Review.

PMID:
10392577
6.

Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

Farzan M, Mirzabekov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H.

Cell. 1999 Mar 5;96(5):667-76.

7.

The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.

Giulian D, Haverkamp LJ, Yu J, Karshin W, Tom D, Li J, Kazanskaia A, Kirkpatrick J, Roher AE.

J Biol Chem. 1998 Nov 6;273(45):29719-26.

8.

Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.

Cras P, van Harskamp F, Hendriks L, Ceuterick C, van Duijn CM, Stefanko SZ, Hofman A, Kros JM, Van Broeckhoven C, Martin JJ.

Acta Neuropathol. 1998 Sep;96(3):253-60.

PMID:
9754958
9.

Mutant genes in familial Alzheimer's disease and transgenic models.

Price DL, Sisodia SS.

Annu Rev Neurosci. 1998;21:479-505. Review.

PMID:
9530504
10.

Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): I--A review of clinical, radiologic and genetic aspects.

Bornebroek M, Haan J, Maat-Schieman ML, Van Duinen SG, Roos RA.

Brain Pathol. 1996 Apr;6(2):111-4. Review.

PMID:
8737926
11.

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

Baldwin ET, Bhat TN, Gulnik S, Hosur MV, Sowder RC 2nd, Cachau RE, Collins J, Silva AM, Erickson JW.

Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6796-800.

12.

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE, Younkin SG.

Science. 1994 May 27;264(5163):1336-40.

PMID:
8191290
13.

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

Näslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P, et al.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8378-82.

14.
15.

Generation of amyloid beta protein from its precursor is sequence specific.

Citron M, Teplow DB, Selkoe DJ.

Neuron. 1995 Mar;14(3):661-70.

16.

Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro.

Pike CJ, Overman MJ, Cotman CW.

J Biol Chem. 1995 Oct 13;270(41):23895-8.

17.

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

Snow AD, Mar H, Nochlin D, Kimata K, Kato M, Suzuki S, Hassell J, Wight TN.

Am J Pathol. 1988 Dec;133(3):456-63.

18.

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GT, Luyendijk W, Frangione B.

Science. 1990 Jun 1;248(4959):1124-6.

PMID:
2111584
19.

Cleavage of amyloid beta peptide during constitutive processing of its precursor.

Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D, Ward PJ.

Science. 1990 Jun 1;248(4959):1122-4.

PMID:
2111583
20.

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).

Van Broeckhoven C, Haan J, Bakker E, Hardy JA, Van Hul W, Wehnert A, Vegter-Van der Vlis M, Roos RA.

Science. 1990 Jun 1;248(4959):1120-2.

PMID:
1971458

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