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Items: 1 to 20 of 168

1.

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH.

J Med Chem. 1999 Jan 28;42(2):260-6.

PMID:
9925731
2.

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K, Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T, Akinaga S.

Cancer Res. 1999 Jun 15;59(12):2931-8.

3.

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D, Neckers LM.

Cell Stress Chaperones. 1998 Jun;3(2):100-8.

4.

Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.

Clevenger RC, Blagg BS.

Org Lett. 2004 Nov 25;6(24):4459-62.

PMID:
15548050
5.

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH.

Cell. 1997 Jul 11;90(1):65-75.

7.

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol.

Dehner A, Furrer J, Richter K, Schuster I, Buchner J, Kessler H.

Chembiochem. 2003 Sep 5;4(9):870-7.

PMID:
12964162
8.

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV.

Mol Endocrinol. 1999 Sep;13(9):1435-48.

PMID:
10478836
9.

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

Bagatell R, Paine-Murrieta GD, Taylor CW, Pulcini EJ, Akinaga S, Benjamin IJ, Whitesell L.

Clin Cancer Res. 2000 Aug;6(8):3312-8.

10.

Altered states: selectively drugging the Hsp90 cancer chaperone.

Workman P.

Trends Mol Med. 2004 Feb;10(2):47-51. Review.

PMID:
15106614
11.

[Molecular chaperone HSP90 as a novel target for cancer chemotherapy].

Miyata Y.

Nihon Yakurigaku Zasshi. 2003 Jan;121(1):33-42. Review. Japanese.

PMID:
12617036
12.

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP.

Cell. 1997 Apr 18;89(2):239-50.

13.

Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site.

Hadden MK, Lubbers DJ, Blagg BS.

Curr Top Med Chem. 2006;6(11):1173-82. Review.

PMID:
16842154
14.

Host cell factor requirement for hepatitis C virus enzyme maturation.

Waxman L, Whitney M, Pollok BA, Kuo LC, Darke PL.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13931-5.

15.

Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation.

Shen Y, Xie Q, Norberg M, Sausville E, Vande Woude G, Wenkert D.

Bioorg Med Chem. 2005 Aug 15;13(16):4960-71.

PMID:
15978816
16.

[Advances in antitumor activity of the hsp90 inhibitor geldanamycin].

Liao ZY, Zhen YS.

Yao Xue Xue Bao. 2001 Sep;36(9):716-20. Review. Chinese. No abstract available.

PMID:
12580116
17.

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.

Piper PW, Millson SH.

Open Biol. 2012 Dec 12;2(12):120138. doi: 10.1098/rsob.120138. Review.

19.

Radanamycin, a macrocyclic chimera of radicicol and geldanamycin.

Wang M, Shen G, Blagg BS.

Bioorg Med Chem Lett. 2006 May 1;16(9):2459-62.

PMID:
16464590
20.

Hsp90 & Co. - a holding for folding.

Buchner J.

Trends Biochem Sci. 1999 Apr;24(4):136-41. Review.

PMID:
10322418

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