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Items: 1 to 20 of 100

1.

Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

Meyer EM, Kuryatov A, Gerzanich V, Lindstrom J, Papke RL.

J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

2.

alpha7 receptor-selective agonists and modes of alpha7 receptor activation.

Papke RL, Meyer E, Nutter T, Uteshev VV.

Eur J Pharmacol. 2000 Mar 30;393(1-3):179-95.

PMID:
10771012
3.

The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL.

Mol Pharmacol. 2004 Jul;66(1):14-24.

4.

Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.

Machu TK, Hamilton ME, Frye TF, Shanklin CL, Harris MC, Sun H, Tenner TE Jr, Soti FS, Kem WR.

J Pharmacol Exp Ther. 2001 Dec;299(3):1112-9.

5.

Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy.

Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK.

Neuropharmacology. 2004 Jun;46(7):1023-38.

PMID:
15081799
6.

Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors.

Uteshev VV, Meyer EM, Papke RL.

Brain Res. 2002 Sep 6;948(1-2):33-46.

PMID:
12383953
7.

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration.

Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F.

Mol Pharmacol. 2004 Jan;65(1):56-67.

8.

Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors.

Horenstein NA, McCormack TJ, Stokes C, Ren K, Papke RL.

J Biol Chem. 2007 Feb 23;282(8):5899-909. Epub 2006 Dec 21.

9.

Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

Kem WR, Mahnir VM, Papke RL, Lingle CJ.

J Pharmacol Exp Ther. 1997 Dec;283(3):979-92.

10.

Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795.

López-Hernández GY, Thinschmidt JS, Morain P, Trocme-Thibierge C, Kem WR, Soti F, Papke RL.

Neuropharmacology. 2009 Mar;56(4):821-30.

13.
14.

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo.

Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, Campbell JE, Decker MW, Donnelly-Roberts D, Elliott RL, Gopalakrishnan M, Holladay MW, Hui YH, Jackson WJ, Kim DJ, Marsh KC, O'Neill A, Prendergast MA, Ryther KB, Sullivan JP, Arneric SP.

Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):231-41.

PMID:
9164577
15.

Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex.

Summers KL, Kem WR, Giacobini E.

Jpn J Pharmacol. 1997 Jun;74(2):139-46.

16.

Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.

Stevens KE, Kem WR, Mahnir VM, Freedman R.

Psychopharmacology (Berl). 1998 Apr;136(4):320-7.

PMID:
9600576
17.

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.

Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM.

Neuroscience. 2007 Aug 10;148(1):230-7. Epub 2007 Jul 20.

PMID:
17640819
18.

N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine.

Zhang R, White NA, Soti FS, Kem WR, Machu TK.

J Pharmacol Exp Ther. 2006 Jun;317(3):1276-84. Epub 2006 Mar 21.

19.
20.

Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site.

Williams DK, Stokes C, Horenstein NA, Papke RL.

J Pharmacol Exp Ther. 2009 Jul;330(1):40-53. doi: 10.1124/jpet.109.151225. Epub 2009 Apr 1.

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