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Genetic analysis of protein kinase B (AKT) in Drosophila.

Staveley BE, Ruel L, Jin J, Stambolic V, Mastronardi FG, Heitzler P, Woodgett JR, Manoukian AS.

Curr Biol. 1998 May 7;8(10):599-602.


3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.


Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

Cho KS, Lee JH, Kim S, Kim D, Koh H, Lee J, Kim C, Kim J, Chung J.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6144-9. Epub 2001 May 8.


Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.

Goyal L, McCall K, Agapite J, Hartwieg E, Steller H.

EMBO J. 2000 Feb 15;19(4):589-97.


Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes.

Wing JP, Zhou L, Schwartz LM, Nambu JR.

Cell Death Differ. 1998 Nov;5(11):930-9. Erratum in: Cell Death Differ 1999 Feb;6(2):212-3.


Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D.

Curr Biol. 1998 Oct 22;8(21):1195-8.


PKB/AKT: functional insights from genetic models.

Scheid MP, Woodgett JR.

Nat Rev Mol Cell Biol. 2001 Oct;2(10):760-8. Review.


Perspectives: cell biology. All creatures great and small.

Leevers SJ.

Science. 1999 Sep 24;285(5436):2082-3. No abstract available.


The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis.

Bachelder RE, Wendt MA, Fujita N, Tsuruo T, Mercurio AM.

J Biol Chem. 2001 Sep 14;276(37):34702-7. Epub 2001 Jul 19.


Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.

Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.

J Biol Chem. 2003 Jun 20;278(25):22374-8. Epub 2003 Apr 8.


The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt.

Stam JC, Geerts WJ, Versteeg HH, Verkleij AJ, van Bergen en Henegouwen PM.

J Biol Chem. 2001 Jul 6;276(27):25176-83. Epub 2001 Apr 25.


Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.

Dijkers PF, van Dijk TB, de Groot RP, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ.

Oncogene. 1999 Jun 3;18(22):3334-42.


CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt.

Fukuda T, Guo L, Shi X, Wu C.

J Cell Biol. 2003 Mar 31;160(7):1001-8. Epub 2003 Mar 24.


The protein kinase B/Akt signalling pathway in human malignancy.

Nicholson KM, Anderson NG.

Cell Signal. 2002 May;14(5):381-95. Review.


grim, a novel cell death gene in Drosophila.

Chen P, Nordstrom W, Gish B, Abrams JM.

Genes Dev. 1996 Jul 15;10(14):1773-82.


Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway.

Khwaja A, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J.

EMBO J. 1997 May 15;16(10):2783-93.


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