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Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.

Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O.

Blood. 1998 May 15;91(10):3734-45.


CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O.

J Biol Chem. 2001 Aug 31;276(35):33282-90. Epub 2001 Jul 6.


Src directly tyrosine-phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway.

Okutani Y, Kitanaka A, Tanaka T, Kamano H, Ohnishi H, Kubota Y, Ishida T, Takahara J.

Oncogene. 2001 Oct 4;20(45):6643-50.


Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3.

Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O.

Blood. 1996 Dec 15;88(12):4415-25.


Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo.

Miura O, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N.

Blood. 1994 Sep 1;84(5):1501-7.


A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis.

Wakao H, Chida D, Damen JE, Krystal G, Miyajima A.

Biochem Biophys Res Commun. 1997 May 8;234(1):198-205.


Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.

Miura O, Miura Y, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N.

Blood. 1994 Dec 15;84(12):4135-41.


JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.

Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN.

Cell. 1993 Jul 30;74(2):227-36.


Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.

Li K, Miller C, Hegde S, Wojchowski D.

J Biol Chem. 2003 Oct 17;278(42):40702-9. Epub 2003 Aug 9.


Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.

Tong W, Zhang J, Lodish HF.

Blood. 2005 Jun 15;105(12):4604-12. Epub 2005 Feb 10.


Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

Wakao H, Harada N, Kitamura T, Mui AL, Miyajima A.

EMBO J. 1995 Jun 1;14(11):2527-35.


STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line.

Iwatsuki K, Endo T, Misawa H, Yokouchi M, Matsumoto A, Ohtsubo M, Mori KJ, Yoshimura A.

J Biol Chem. 1997 Mar 28;272(13):8149-52.


CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.

Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A.

Blood. 1997 May 1;89(9):3148-54.

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