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Items: 1 to 20 of 489

1.

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.

Romano PR, Garcia-Barrio MT, Zhang X, Wang Q, Taylor DR, Zhang F, Herring C, Mathews MB, Qin J, Hinnebusch AG.

Mol Cell Biol. 1998 Apr;18(4):2282-97.

2.

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha.

Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE.

Mol Cell Biol. 2005 Apr;25(8):3063-75.

3.

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG.

J Biol Chem. 2001 Jul 6;276(27):24946-58. Epub 2001 May 3.

4.

Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop.

Dey M, Mann BR, Anshu A, Mannan MA.

J Biol Chem. 2014 Feb 28;289(9):5747-57. doi: 10.1074/jbc.M113.527796. Epub 2013 Dec 13.

6.

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG.

Mol Cell Biol. 1997 Aug;17(8):4474-89.

8.
12.

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

Dever TE, Chen JJ, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG, Hinnebusch AG.

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4616-20.

13.

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

Kubota H, Ota K, Sakaki Y, Ito T.

J Biol Chem. 2001 May 18;276(20):17591-6. Epub 2001 Feb 28.

15.

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B, Hinnebusch AG.

Mol Cell Biol. 1992 Dec;12(12):5801-15.

16.
18.

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.

Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG.

Cell. 1992 Feb 7;68(3):585-96.

PMID:
1739968
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