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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ.

Science. 1997 Sep 5;277(5331):1497-501.


Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.

Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H.

Science. 1997 Sep 5;277(5331):1501-5.


Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1.

Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T.

Nature. 1998 Oct 1;395(6701):507-10.


Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Furnari B, Rhind N, Russell P.

Science. 1997 Sep 5;277(5331):1495-7.


Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1.

Furnari B, Blasina A, Boddy MN, McGowan CH, Russell P.

Mol Biol Cell. 1999 Apr;10(4):833-45.


Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.

Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ.

Science. 1999 Nov 5;286(5442):1166-71.


Replication checkpoint enforced by kinases Cds1 and Chk1.

Boddy MN, Furnari B, Mondesert O, Russell P.

Science. 1998 May 8;280(5365):909-12.


Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Chen MS, Ryan CE, Piwnica-Worms H.

Mol Cell Biol. 2003 Nov;23(21):7488-97.


Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint.

Baber-Furnari BA, Rhind N, Boddy MN, Shanahan P, Lopez-Girona A, Russell P.

Mol Biol Cell. 2000 Jan;11(1):1-11.


A DNA damage checkpoint meets the cell cycle engine.

Weinert T.

Science. 1997 Sep 5;277(5331):1450-1. No abstract available.


Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

Hutchins JR, Dikovskaya D, Clarke PR.

Mol Biol Cell. 2003 Oct;14(10):4003-14. Epub 2003 Jul 11. Erratum in: Mol Biol Cell. 2005 Mar;16(3):1568.


A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.

Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH.

Curr Biol. 1999 Jan 14;9(1):1-10.


The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H.

J Biol Chem. 2000 Feb 25;275(8):5600-5.


Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.

Matsuoka S, Huang M, Elledge SJ.

Science. 1998 Dec 4;282(5395):1893-7.


The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts.

Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG.

J Cell Biol. 1998 Sep 21;142(6):1559-69.


Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.

Caspari T, Hilditch V.

PLoS One. 2015 Jul 1;10(7):e0130748. doi: 10.1371/journal.pone.0130748. eCollection 2015.


SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.

Genes Dev. 2003 Dec 15;17(24):3062-74. Epub 2003 Dec 17.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.


Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.

den Elzen NR, O'Connell MJ.

EMBO J. 2004 Feb 25;23(4):908-18. Epub 2004 Feb 5.


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