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Items: 1 to 20 of 275

1.

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW.

J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95.

2.

Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.

Hawkinson JE, Acosta-Burruel M, Yang KC, Hogenkamp DJ, Chen JS, Lan NC, Drewe JA, Whittemore ER, Woodward RM, Carter RB, Upasani RB.

J Pharmacol Exp Ther. 1998 Oct;287(1):198-207.

3.

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM.

Mol Pharmacol. 1996 May;49(5):897-906.

PMID:
8622640
5.

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.

Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee KW.

Psychopharmacology (Berl). 2014 Sep;231(17):3517-24. doi: 10.1007/s00213-014-3494-5. Epub 2014 Feb 28.

PMID:
24682501
6.

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

Hawkinson JE, Kimbrough CL, Belelli D, Lambert JJ, Purdy RH, Lan NC.

Mol Pharmacol. 1994 Nov;46(5):977-85.

PMID:
7969089
7.

Reversal of behavioral effects of pentylenetetrazol by the neuroactive steroid ganaxolone.

Beekman M, Ungard JT, Gasior M, Carter RB, Dijkstra D, Goldberg SR, Witkin JM.

J Pharmacol Exp Ther. 1998 Mar;284(3):868-77.

8.

Characterization of the anticonvulsant properties of F-721.

Swinyard EA, Wolf HH, White HS, Skeen GA, Stark LG, Albertson T, Pong SF, Drust EG.

Epilepsy Res. 1993 May;15(1):35-45.

PMID:
8391982
9.
10.

Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593.

Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC.

Psychopharmacology (Berl). 1997 Nov;134(1):46-54.

PMID:
9399366
12.

Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.

McCauley LD, Liu V, Chen JS, Hawkinson JE, Lan NC, Gee KW.

Mol Pharmacol. 1995 Feb;47(2):354-62.

PMID:
7870044
15.

Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice.

Kaminski RM, Gasior M, Carter RB, Witkin JM.

Eur J Pharmacol. 2003 Aug 8;474(2-3):217-22.

PMID:
12921865
16.

Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.

Reddy DS, Rogawski MA.

Epilepsy Res. 2010 May;89(2-3):254-60. doi: 10.1016/j.eplepsyres.2010.01.009. Epub 2010 Feb 20.

17.

Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress.

Concas A, Mostallino MC, Perra C, Lener R, Roscetti G, Barbaccia ML, Purdy RH, Biggio G.

Br J Pharmacol. 1996 Jun;118(4):839-46.

19.
20.

Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.

Sanna E, Murgia A, Casula A, Usala M, Maciocco E, Tuligi G, Biggio G.

Neuropharmacology. 1996;35(12):1753-60.

PMID:
9076754

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