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Items: 1 to 20 of 122

1.

A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.

Schreuder H, Tardif C, Trump-Kallmeyer S, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW.

Nature. 1997 Mar 13;386(6621):194-200.

PMID:
9062194
2.

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.

Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ.

Nature. 1997 Mar 13;386(6621):190-4.

PMID:
9062193
3.

X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.

Vigers GP, Dripps DJ, Edwards CK 3rd, Brandhuber BJ.

J Biol Chem. 2000 Nov 24;275(47):36927-33.

4.

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

Evans RJ, Bray J, Childs JD, Vigers GP, Brandhuber BJ, Skalicky JJ, Thompson RC, Eisenberg SP.

J Biol Chem. 1995 May 12;270(19):11477-83.

5.

Solution structure of human interleukin-1 receptor antagonist protein.

Stockman BJ, Scahill TA, Strakalaitis NA, Brunner DP, Yem AW, Deibel MR Jr.

FEBS Lett. 1994 Jul 25;349(1):79-83.

6.

Crystals of soluble interleukin-1 receptor complexed with its natural antagonist reveal a 1:1 receptor-ligand complex.

Schreuder H, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW.

FEBS Lett. 1995 Oct 2;373(1):39-40.

7.

Deletion mutants of human interleukin 1 beta with significantly reduced agonist properties: search for the agonist/antagonist switch in ligands to the interleukin 1 receptors.

Simoncsits A, Bristulf J, Tjörnhammar ML, Cserzö M, Pongor S, Rybakina E, Gatti S, Bartfai T.

Cytokine. 1994 Mar;6(2):206-14.

PMID:
8032002
9.

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.

Dunn EF, Gay NJ, Bristow AF, Gearing DP, O'Neill LA, Pei XY.

Biochemistry. 2003 Sep 23;42(37):10938-44.

PMID:
12974628
10.

Mapping of receptor binding sites on IL-1 beta by reconstruction of IL-1ra-like domains.

Boraschi D, Bossù P, Ruggiero P, Tagliabue A, Bertini R, Macchia G, Gasbarro C, Pellegrini L, Melillo G, Ulisse E, Visconti U, Bizzarri C, Del Grosso E, Mackay AR, Frascotti G, Frigerio F, Grifantini R, Grandi G.

J Immunol. 1995 Nov 15;155(10):4719-25.

PMID:
7594472
11.

The search for inhibitors of interleukin-1 based on the sequence of interleukin-1 receptor antagonist.

Wieczorek Z, Kluczyk A, Slon-Usakiewicz JJ, Siemion IZ.

Biomed Pept Proteins Nucleic Acids. 1996-1997;2(4):123-9.

PMID:
9575352
12.

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

Khan JA, Brint EK, O'Neill LA, Tong L.

J Biol Chem. 2004 Jul 23;279(30):31664-70. Epub 2004 Apr 30.

13.

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution.

Vigers GP, Caffes P, Evans RJ, Thompson RC, Eisenberg SP, Brandhuber BJ.

J Biol Chem. 1994 Apr 29;269(17):12874-9.

PMID:
8175703
14.

Identification of the domain in the human interleukin-11 receptor that mediates ligand binding.

Schleinkofer K, Dingley A, Tacken I, Federwisch M, Müller-Newen G, Heinrich PC, Vusio P, Jacques Y, Grötzinger J.

J Mol Biol. 2001 Feb 16;306(2):263-74.

PMID:
11237599
15.

A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor.

Smith DE, Ketchem RR, Moore H, Anderson Z, Renshaw BR, Friend DJ, Sims JE.

J Biol Chem. 2002 Dec 6;277(49):47619-25. Epub 2002 Sep 28.

16.

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG.

J Biol Chem. 2004 Jun 18;279(25):26500-8. Epub 2004 Apr 1.

17.

Model structures and action of interleukin 1 and its antagonist.

Oldfield TJ, Murray-Rust P, Hubbard RE.

Protein Eng. 1993 Nov;6(8):865-71.

PMID:
8309934
18.

The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling.

Radons J, Dove S, Neumann D, Altmann R, Botzki A, Martin MU, Falk W.

J Biol Chem. 2003 Dec 5;278(49):49145-53. Epub 2003 Sep 17.

19.

Identification of an interleukin-15alpha receptor-binding site on human interleukin-15.

Bernard J, Harb C, Mortier E, Quéméner A, Meloen RH, Vermot-Desroches C, Wijdeness J, van Dijken P, Grötzinger J, Slootstra JW, Plet A, Jacques Y.

J Biol Chem. 2004 Jun 4;279(23):24313-22. Epub 2004 Mar 23.

20.

Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA.

J Immunol. 2001 Aug 1;167(3):1440-6.

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