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Items: 1 to 20 of 144

1.

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.

Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2025-30.

3.
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Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

Marambaud P, Alves da Costa C, Ancolio K, Checler F.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):134-8.

PMID:
9813158
5.

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, Ihara Y.

J Neurochem. 1998 Jul;71(1):313-22.

6.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
7.

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.

Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ.

J Biol Chem. 1997 Mar 21;272(12):7977-82.

8.

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

Jacobsen H, Reinhardt D, Brockhaus M, Bur D, Kocyba C, Kurt H, Grim MG, Baumeister R, Loetscher H.

J Biol Chem. 1999 Dec 3;274(49):35233-9.

10.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
11.

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A.

Neurosci Lett. 1999 Apr 9;265(1):61-3.

PMID:
10327206
12.

Abeta42, presenilins, and Alzheimer's disease.

Iwatsubo T.

Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S11-3.

PMID:
9562460
13.

Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.

Fang B, Jia L, Jia J.

Neurosci Lett. 2006 Oct 2;406(1-2):33-7. Epub 2006 Aug 17.

PMID:
16916581
14.

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

Hashimoto Y, Niikura T, Ito Y, Kita Y, Terashita K, Nishimoto I.

J Pharmacol Exp Ther. 2002 Mar;300(3):736-45.

15.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S.

Nat Med. 1996 Aug;2(8):864-70.

PMID:
8705854
16.

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.

Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T.

J Neurosci. 1999 Dec 15;19(24):10627-34.

17.

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG.

J Neurosci. 2000 Dec 1;20(23):8717-26.

18.

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.

Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.

PMID:
17210196
19.

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.

Leimer U, Lun K, Romig H, Walter J, Grünberg J, Brand M, Haass C.

Biochemistry. 1999 Oct 12;38(41):13602-9.

PMID:
10521267
20.

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