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Items: 1 to 20 of 130

1.

Discovering high-affinity ligands for proteins: SAR by NMR.

Shuker SB, Hajduk PJ, Meadows RP, Fesik SW.

Science. 1996 Nov 29;274(5292):1531-4.

PMID:
8929414
2.

An automated method for dynamic ligand design.

Miranker A, Karplus M.

Proteins. 1995 Dec;23(4):472-90.

PMID:
8749844
3.

Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.

Fehr T, Sanglier JJ, Schuler W, Gschwind L, Ponelle M, Schilling W, Wioland C.

J Antibiot (Tokyo). 1996 Mar;49(3):230-3.

4.
5.

Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein.

Muegge I, Martin YC, Hajduk PJ, Fesik SW.

J Med Chem. 1999 Jul 15;42(14):2498-503.

PMID:
10411471
6.
8.

Consensus preferred hydration sites in six FKBP12-drug complexes.

Faerman CH, Karplus PA.

Proteins. 1995 Sep;23(1):1-11.

PMID:
8539241
9.
10.

NMR-based screening methods for lead discovery.

Vogtherr M, Fiebig K.

EXS. 2003;(93):183-202. Review.

PMID:
12613177
11.

A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin.

Leach KL, Ruff VA, Yem AW, Deibel MR Jr.

J Immunoassay. 1994 Nov;15(4):339-55.

PMID:
7530727
12.

FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes.

DeCenzo MT, Park ST, Jarrett BP, Aldape RA, Futer O, Murcko MA, Livingston DJ.

Protein Eng. 1996 Feb;9(2):173-80.

PMID:
9005438
13.
14.

Conformational polymorphism in peptidic and nonpeptidic drug molecules.

Taylor P, Mikol V, Kallen J, Burkhard P, Walkinshaw MD.

Biopolymers. 1996;40(5):585-92.

PMID:
9101762
15.

Structure-based drug design ten years on.

Robertus J.

Nat Struct Biol. 1994 Jun;1(6):352-4. No abstract available.

PMID:
7545074
16.

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.

Hajduk PJ, Dinges J, Miknis GF, Merlock M, Middleton T, Kempf DJ, Egan DA, Walter KA, Robins TS, Shuker SB, Holzman TF, Fesik SW.

J Med Chem. 1997 Sep 26;40(20):3144-50.

PMID:
9379433
17.

[Discovering high-affinity ligands for proteins: SAR by NMR].

Kamisuki S, Uesugi M.

Tanpakushitsu Kakusan Koso. 2007 Oct;52(13 Suppl):1818-9. Review. Japanese. No abstract available.

PMID:
18051441
18.

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Wyss DF, Arasappan A, Senior MM, Wang YS, Beyer BM, Njoroge FG, McCoy MA.

J Med Chem. 2004 May 6;47(10):2486-98.

PMID:
15115392
20.

Fragment-based synthesis and SAR of modified FKBP ligands: influence of different linking on binding affinity.

Röhrig CH, Loch C, Guan JY, Siegal G, Overhand M.

ChemMedChem. 2007 Jul;2(7):1054-70.

PMID:
17541991

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