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The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.

Dev K, Qiu H, Dong J, Zhang F, Barthlme D, Hinnebusch AG.

Mol Cell Biol. 2010 Nov;30(21):5218-33. doi: 10.1128/MCB.00265-10. Epub 2010 Aug 30.


eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

Pavitt GD, Ramaiah KV, Kimball SR, Hinnebusch AG.

Genes Dev. 1998 Feb 15;12(4):514-26.


Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

Asano K, Krishnamoorthy T, Phan L, Pavitt GD, Hinnebusch AG.

EMBO J. 1999 Mar 15;18(6):1673-88. Erratum in: EMBO J 1999 May 4;18(9):2670.


Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B.

Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS.

J Biol Chem. 1998 Jan 30;273(5):3039-44.


Complex formation by positive and negative translational regulators of GCN4.

Cigan AM, Foiani M, Hannig EM, Hinnebusch AG.

Mol Cell Biol. 1991 Jun;11(6):3217-28.


Serine 48 in initiation factor 2 alpha (eIF2 alpha) is required for high-affinity interaction between eIF2 alpha(P) and eIF2B.

Sudhakar A, Krishnamoorthy T, Jain A, Chatterjee U, Hasnain SE, Kaufman RJ, Ramaiah KV.

Biochemistry. 1999 Nov 16;38(46):15398-405.


eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast.

Price NT, Mellor H, Craddock BL, Flowers KM, Kimball SR, Wilmer T, Jefferson LS, Proud CG.

Biochem J. 1996 Sep 1;318 ( Pt 2):637-43.


Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.

Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG.

J Mol Biol. 2009 Sep 25;392(3):701-22. doi: 10.1016/j.jmb.2009.07.030. Epub 2009 Jul 17.


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