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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D.

EMBO J. 1996 May 15;15(10):2371-80.


Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D.

Kidney Int. 2000 Mar;57(3):809-15. Review.


Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.

Snyder PM, Olson DR, McDonald FJ, Bucher DB.

J Biol Chem. 2001 Jul 27;276(30):28321-6. Epub 2001 May 18.


Solution structure of a Nedd4 WW domain-ENaC peptide complex.

Kanelis V, Rotin D, Forman-Kay JD.

Nat Struct Biol. 2001 May;8(5):407-12.


Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O.

J Clin Invest. 1999 Mar;103(5):667-73.


A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O.

FASEB J. 2001 Jan;15(1):204-214.


Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel.

Henry PC, Kanelis V, O'Brien MC, Kim B, Gautschi I, Forman-Kay J, Schild L, Rotin D.

J Biol Chem. 2003 May 30;278(22):20019-28. Epub 2003 Mar 22.


NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel.

Kanelis V, Farrow NA, Kay LE, Rotin D, Forman-Kay JD.

Biochem Cell Biol. 1998;76(2-3):341-50.


Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome.

Goulet CC, Volk KA, Adams CM, Prince LS, Stokes JB, Snyder PM.

J Biol Chem. 1998 Nov 6;273(45):30012-7.


Liddle's syndrome: a novel mouse Nedd4 isoform regulates the activity of the epithelial Na(+) channel.

Kamynina E, Debonneville C, Hirt RP, Staub O.

Kidney Int. 2001 Aug;60(2):466-71. Review.


All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.

Harvey KF, Dinudom A, Komwatana P, Jolliffe CN, Day ML, Parasivam G, Cook DI, Kumar S.

J Biol Chem. 1999 Apr 30;274(18):12525-30.


Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC).

Staub O, Yeger H, Plant PJ, Kim H, Ernst SA, Rotin D.

Am J Physiol. 1997 Jun;272(6 Pt 1):C1871-80.


Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.

McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM.

Am J Physiol Renal Physiol. 2002 Sep;283(3):F431-6.


The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.

Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S.

FASEB J. 2003 Jan;17(1):70-2. Epub 2002 Nov 1.


The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization.

Plant PJ, Yeger H, Staub O, Howard P, Rotin D.

J Biol Chem. 1997 Dec 19;272(51):32329-36.


Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits.

Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ.

Biochem J. 2000 Feb 1;345 Pt 3:503-9.


Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

Knight KK, Olson DR, Zhou R, Snyder PM.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2805-8. Epub 2006 Feb 13.


Patch-clamp studies on epithelial sodium channels in salivary duct cells.

Cook DI, Dinudom A, Komwatana P, Kumar S, Young JA.

Cell Biochem Biophys. 2002;36(2-3):105-13. Review.


Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.

Itani OA, Campbell JR, Herrero J, Snyder PM, Thomas CP.

Am J Physiol Renal Physiol. 2003 Nov;285(5):F916-29. Epub 2003 Jul 22.

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