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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.

Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM.

J Biol Chem. 1996 Jul 12;271(28):16720-4.


Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.

Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM.

Curr Biol. 1996 Jul 1;6(7):897-9.


Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product.

Hugunin M, Quintal LJ, Mankovich JA, Ghayur T.

J Biol Chem. 1996 Feb 16;271(7):3517-22.


Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.

Robertson NM, Zangrilli J, Fernandes-Alnemri T, Friesen PD, Litwack G, Alnemri ES.

Cancer Res. 1997 Jan 1;57(1):43-7.


Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors.

Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ.

J Biol Chem. 1996 Jul 12;271(28):16850-5.


Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

Hasegawa J, Kamada S, Kamiike W, Shimizu S, Imazu T, Matsuda H, Tsujimoto Y.

Cancer Res. 1996 Apr 15;56(8):1713-8. Erratum in: Cancer Res 1996 Jul 1;56(13):3152.


FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM.

Cell. 1996 Jun 14;85(6):817-27.


FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.

Muzio M, Salvesen GS, Dixit VM.

J Biol Chem. 1997 Jan 31;272(5):2952-6.


Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis.

Srinivasan A, Foster LM, Testa MP, Ord T, Keane RW, Bredesen DE, Kayalar C.

J Neurosci. 1996 Sep 15;16(18):5654-60.


Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.

Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM.

Science. 1997 Feb 21;275(5303):1122-6.


Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.

Wang L, Miura M, Bergeron L, Zhu H, Yuan J.

Cell. 1994 Sep 9;78(5):739-50.


Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.

Nature. 1995 Jul 6;376(6535):37-43.


Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.

Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Dröge W, Krammer PH, Fiers W, Schulze-Osthoff K.

Nature. 1995 May 4;375(6526):81-3.


Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.

Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.

Cell. 1995 Jun 2;81(5):801-9.

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