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Items: 1 to 20 of 115

1.

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

Aiken C, Konner J, Landau NR, Lenburg ME, Trono D.

Cell. 1994 Mar 11;76(5):853-64.

PMID:
8124721
2.

Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef.

Gratton S, Yao XJ, Venkatesan S, Cohen EA, Sékaly RP.

J Immunol. 1996 Oct 15;157(8):3305-11.

PMID:
8871625
3.

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.

Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC.

Curr Biol. 1998 Nov 5;8(22):1235-8.

4.

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.

Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D.

Immunity. 1997 Jan;6(1):67-77.

5.

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.

Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T.

Curr Biol. 1998 Nov 5;8(22):1239-42.

6.

The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs.

Schaefer TM, Bell I, Pfeifer ME, Ghosh M, Trible RP, Fuller CL, Ashman C, Reinhart TA.

Virology. 2002 Oct 10;302(1):106-22.

7.

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.

Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier JL, Trono D.

Cell. 1999 Apr 2;97(1):63-73.

9.

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.

Schwartz O, Dautry-Varsat A, Goud B, Maréchal V, Subtil A, Heard JM, Danos O.

J Virol. 1995 Jan;69(1):528-33.

10.

HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent.

Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ.

J Immunol. 2005 Sep 1;175(5):3157-64. Erratum in: J Immunol. 2006 Feb 15;176(4):2669.

11.
12.

Myristoylation-dependent binding of HIV-1 Nef to CD4.

Harris MP, Neil JC.

J Mol Biol. 1994 Aug 12;241(2):136-42.

PMID:
8057354
13.

Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation.

Peng B, Robert-Guroff M.

Immunol Lett. 2001 Oct 1;78(3):195-200.

PMID:
11578695
15.

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.

Rose JJ, Janvier K, Chandrasekhar S, Sekaly RP, Bonifacino JS, Venkatesan S.

J Biol Chem. 2005 Mar 4;280(9):7413-26. Epub 2004 Dec 16.

17.
18.

Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.

Jin YJ, Cai CY, Zhang X, Burakoff SJ.

J Immunol. 2008 Jun 15;180(12):7878-86.

19.

Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis.

Cai CY, Zhang X, Sinko PJ, Burakoff SJ, Jin YJ.

J Immunol. 2011 May 15;186(10):5807-14. doi: 10.4049/jimmunol.1003506. Epub 2011 Apr 11.

20.

Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.

Laguette N, Brégnard C, Bouchet J, Benmerah A, Benichou S, Basmaciogullari S.

J Virol. 2009 Jul;83(14):7117-28. doi: 10.1128/JVI.01648-08. Epub 2009 May 13.

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