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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7884-8.


Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der Schoot CE, Ludwig WD, Karpas A, et al.

Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8538-42.


A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.

Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA.

Nat Genet. 1992 Oct;2(2):113-8. Erratum in: Nat Genet. 1993 Aug;4(4):431.


Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).

Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F.

Oncogene. 1997 Jan 16;14(2):195-202.


t(11;14)(q23;q24) generates an MLL-human gephyrin fusion gene along with a de facto truncated MLL in acute monoblastic leukemia.

Kuwada N, Kimura F, Matsumura T, Yamashita T, Nakamura Y, Wakimoto N, Ikeda T, Sato K, Motoyoshi K.

Cancer Res. 2001 Mar 15;61(6):2665-9.


Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23).

Dahéron L, Veinstein A, Brizard F, Drabkin H, Lacotte L, Guilhot F, Larsen CJ, Brizard A, Roche J.

Genes Chromosomes Cancer. 2001 Aug;31(4):382-9.


The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.

Chen CS, Hilden JM, Frestedt J, Domer PH, Moore R, Korsmeyer SJ, Kersey JH.

Blood. 1993 Aug 15;82(4):1080-5.


Cloning of several species of MLL/MEN chimeric cDNAs in myeloid leukemia with t(11;19)(q23;p13.1) translocation.

Mitani K, Kanda Y, Ogawa S, Tanaka T, Inazawa J, Yazaki Y, Hirai H.

Blood. 1995 Apr 15;85(8):2017-24.


Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD.

Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12110-4.


Three-way translocation involves MLL, MLLT3, and a novel cell cycle control gene, FLJ10374, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3).

Vieira L, Sousa AC, Matos P, Marques B, Alaiz H, Ribeiro MJ, Braga P, da Silva MG, Jordan P.

Genes Chromosomes Cancer. 2006 May;45(5):455-69.


A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.

Morrissey J, Tkachuk DC, Milatovich A, Francke U, Link M, Cleary ML.

Blood. 1993 Mar 1;81(5):1124-31.


GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24).

Eguchi M, Eguchi-Ishimae M, Seto M, Morishita K, Suzuki K, Ueda R, Ueda K, Kamada N, Greaves M.

Genes Chromosomes Cancer. 2001 Nov;32(3):212-21.


Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.

Super HG, Strissel PL, Sobulo OM, Burian D, Reshmi SC, Roe B, Zeleznik-Le NJ, Diaz MO, Rowley JD.

Genes Chromosomes Cancer. 1997 Oct;20(2):185-95.


AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner.

Hayette S, Cornillet-Lefebvre P, Tigaud I, Struski S, Forissier S, Berchet A, Doll D, Gillot L, Brahim W, Delabesse E, Magaud JP, Rimokh R.

Cancer Res. 2005 Aug 1;65(15):6521-5.


The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E.

Cell. 1992 Nov 13;71(4):701-8.


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