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Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense.

Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43. doi: 10.1073/pnas.1412767111. Epub 2014 Oct 14.


Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES.

J Biol Chem. 2013 Oct 25;288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9.


RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J.

Cell Host Microbe. 2015 Feb 11;17(2):229-42. doi: 10.1016/j.chom.2015.01.002.


Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles.

Ali M, Roback L, Mocarski ES.

J Biol Chem. 2019 Jan 18;294(3):991-1004. doi: 10.1074/jbc.RA118.004651. Epub 2018 Nov 30.


Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1.

Yu X, Li Y, Chen Q, Su C, Zhang Z, Yang C, Hu Z, Hou J, Zhou J, Gong L, Jiang X, Zheng C, He S.

J Virol. 2015 Nov 11;90(2):1088-95. doi: 10.1128/JVI.02446-15. Print 2016 Jan 15.


Herpes simplex virus suppresses necroptosis in human cells.

Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2015 Feb 11;17(2):243-51. doi: 10.1016/j.chom.2015.01.003.


DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

Upton JW, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2012 Mar 15;11(3):290-7. doi: 10.1016/j.chom.2012.01.016.


Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.

He S, Liang Y, Shao F, Wang X.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20054-9. doi: 10.1073/pnas.1116302108. Epub 2011 Nov 28.


Suppression of RIP3-dependent necroptosis by human cytomegalovirus.

Omoto S, Guo H, Talekar GR, Roback L, Kaiser WJ, Mocarski ES.

J Biol Chem. 2015 May 1;290(18):11635-48. doi: 10.1074/jbc.M115.646042. Epub 2015 Mar 16.


Manipulation of apoptosis and necroptosis signaling by herpesviruses.

Guo H, Kaiser WJ, Mocarski ES.

Med Microbiol Immunol. 2015 Jun;204(3):439-48. doi: 10.1007/s00430-015-0410-5. Epub 2015 Apr 1. Review.


Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling.

Chen W, Zhou Z, Li L, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J.

J Biol Chem. 2013 Jun 7;288(23):16247-61. doi: 10.1074/jbc.M112.435545. Epub 2013 Apr 23.


Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.

Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5322-7. doi: 10.1073/pnas.1200012109. Epub 2012 Mar 15.


Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Mostafa HH, Thompson TW, Konen AJ, Haenchen SD, Hilliard JG, Macdonald SJ, Morrison LA, Davido DJ.

J Virol. 2018 Mar 14;92(7). pii: e01654-17. doi: 10.1128/JVI.01654-17. Print 2018 Apr 1.


Necroptosis: The Trojan horse in cell autonomous antiviral host defense.

Mocarski ES, Guo H, Kaiser WJ.

Virology. 2015 May;479-480:160-6. doi: 10.1016/j.virol.2015.03.016. Epub 2015 Mar 24. Review.


The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.

Dufour F, Sasseville AM, Chabaud S, Massie B, Siegel RM, Langelier Y.

Apoptosis. 2011 Mar;16(3):256-71. doi: 10.1007/s10495-010-0560-2.


Virus inhibition of RIP3-dependent necrosis.

Upton JW, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2010 Apr 22;7(4):302-13. doi: 10.1016/j.chom.2010.03.006.


The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling.

Cotter CR, Kim WK, Nguyen ML, Yount JS, López CB, Blaho JA, Moran TM.

J Virol. 2011 Dec;85(23):12662-72. doi: 10.1128/JVI.05557-11. Epub 2011 Sep 21.


Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK.

Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.


Structural insights into RIP3-mediated necroptotic signaling.

Xie T, Peng W, Yan C, Wu J, Gong X, Shi Y.

Cell Rep. 2013 Oct 17;5(1):70-8. doi: 10.1016/j.celrep.2013.08.044. Epub 2013 Oct 3.

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