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The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.

Romero-Pozuelo J, Dason JS, Mansilla A, Baños-Mateos S, Sardina JL, Chaves-Sanjuán A, Jurado-Gómez J, Santana E, Atwood HL, Hernández-Hernández Á, Sánchez-Barrena MJ, Ferrús A.

J Cell Sci. 2014 Oct 1;127(Pt 19):4246-59. doi: 10.1242/jcs.152603. Epub 2014 Jul 29.


Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.

Mansilla A, Chaves-Sanjuan A, Campillo NE, Semelidou O, Martínez-González L, Infantes L, González-Rubio JM, Gil C, Conde S, Skoulakis EM, Ferrús A, Martínez A, Sánchez-Barrena MJ.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E999-E1008. doi: 10.1073/pnas.1611089114. Epub 2017 Jan 24.


Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication.

Sánchez-Gracia A, Romero-Pozuelo J, Ferrús A.

BMC Evol Biol. 2010 Feb 19;10:54. doi: 10.1186/1471-2148-10-54.


Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.

Romero-Pozuelo J, Dason JS, Atwood HL, Ferrús A.

Eur J Neurosci. 2007 Nov;26(9):2428-43. Epub 2007 Oct 26.


Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth.

Dason JS, Romero-Pozuelo J, Marin L, Iyengar BG, Klose MK, Ferrús A, Atwood HL.

J Cell Sci. 2009 Nov 15;122(Pt 22):4109-21. doi: 10.1242/jcs.055095. Epub 2009 Oct 27.


Frq2 from Drosophila melanogaster: cloning, expression, purification, crystallization and preliminary X-ray analysis.

Baños-Mateos S, Chaves-Sanjuán A, Mansilla A, Ferrús A, Sánchez-Barrena MJ.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):530-4. doi: 10.1107/S2053230X14005408. Epub 2014 Mar 25.


Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.

Roca C, Martinez-González L, Daniel-Mozo M, Sastre J, Infantes L, Mansilla A, Chaves-Sanjuan A, González-Rubio JM, Gil C, Cañada FJ, Martinez A, Sanchez-Barrena MJ, Campillo NE.

J Med Chem. 2018 Jul 26;61(14):5910-5921. doi: 10.1021/acs.jmedchem.8b00088. Epub 2018 Jul 17.


Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.

Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y.

Biochem J. 2007 Sep 15;406(3):383-8.


Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.

Ruisu K, Kask K, Meier R, Saare M, Raid R, Veraksitš A, Karis A, Tõnissoo T, Pooga M.

PLoS One. 2013 Aug 16;8(8):e74031. doi: 10.1371/journal.pone.0074031. eCollection 2013.


Frequenin--a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system.

Pongs O, Lindemeier J, Zhu XR, Theil T, Engelkamp D, Krah-Jentgens I, Lambrecht HG, Koch KW, Schwemer J, Rivosecchi R, et al.

Neuron. 1993 Jul;11(1):15-28.


Molecular cloning and functional characterization of the Xenopus Ca(2+)-binding protein frequenin.

Olafsson P, Wang T, Lu B.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):8001-5.


NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response.

Amoureux MC, Nicolas S, Rougon G.

PLoS One. 2012;7(2):e32216. doi: 10.1371/journal.pone.0032216. Epub 2012 Feb 22.


Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse.

Kask K, Ruisu K, Tikker L, Karis K, Saare M, Meier R, Karis A, Tõnissoo T, Pooga M.

Dev Neurobiol. 2015 Sep;75(9):984-1002. doi: 10.1002/dneu.22264. Epub 2015 Jan 16.


Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission.

Chen XL, Zhong ZG, Yokoyama S, Bark C, Meister B, Berggren PO, Roder J, Higashida H, Jeromin A.

J Physiol. 2001 May 1;532(Pt 3):649-59.


Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.

Rajebhosale M, Greenwood S, Vidugiriene J, Jeromin A, Hilfiker S.

J Biol Chem. 2003 Feb 21;278(8):6075-84. Epub 2002 Dec 5.


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