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Items: 1 to 20 of 185

1.

Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-κB-dependent cytokines.

Love AC, Schwartz I, Petzke MM.

Infect Immun. 2014 Jun;82(6):2405-16. doi: 10.1128/IAI.01617-14. Epub 2014 Mar 24.

2.

Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.

Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I.

J Immunol. 2009 Oct 15;183(8):5279-92. doi: 10.4049/jimmunol.0901390. Epub 2009 Sep 30.

3.

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes.

Cervantes JL, La Vake CJ, Weinerman B, Luu S, O'Connell C, Verardi PH, Salazar JC.

J Leukoc Biol. 2013 Dec;94(6):1231-41. doi: 10.1189/jlb.0413206. Epub 2013 Aug 1.

4.

Induction of indoleamine 2,3-dioxygenase by Borrelia burgdorferi in human immune cells correlates with pathogenic potential.

Love AC, Schwartz I, Petzke MM.

J Leukoc Biol. 2015 Feb;97(2):379-90. doi: 10.1189/jlb.4A0714-339R. Epub 2014 Nov 24.

5.

Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36.

Krupna-Gaylord MA, Liveris D, Love AC, Wormser GP, Schwartz I, Petzke MM.

PLoS One. 2014 Jun 19;9(6):e100174. doi: 10.1371/journal.pone.0100174. eCollection 2014.

6.

Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.

Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD.

PLoS Pathog. 2009 May;5(5):e1000444. doi: 10.1371/journal.ppat.1000444. Epub 2009 May 22.

7.

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.

Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3683-8. doi: 10.1073/pnas.1013776108. Epub 2011 Feb 14.

8.

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J.

PLoS One. 2009 May 25;4(5):e5674. doi: 10.1371/journal.pone.0005674.

9.

The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.

Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ.

Infect Immun. 2010 Jul;78(7):3144-53. doi: 10.1128/IAI.01070-09. Epub 2010 Apr 19.

10.

Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells.

Osterlund P, Veckman V, Sirén J, Klucher KM, Hiscott J, Matikainen S, Julkunen I.

J Virol. 2005 Aug;79(15):9608-17.

11.

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.

Fang L, Choudhary S, Tian B, Boldogh I, Yang C, Ivanciuc T, Ma Y, Garofalo RP, Brasier AR.

J Virol. 2015 Mar;89(5):2628-42. doi: 10.1128/JVI.02458-14. Epub 2014 Dec 17.

12.

Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes.

Cruz AR, Moore MW, La Vake CJ, Eggers CH, Salazar JC, Radolf JD.

Infect Immun. 2008 Jan;76(1):56-70. Epub 2007 Oct 15.

13.

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P.

J Exp Med. 2005 May 2;201(9):1435-46. Epub 2005 Apr 25.

14.

Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.

Sadik CD, Hunfeld KP, Bachmann M, Kraiczy P, Eberhardt W, Brade V, Pfeilschifter J, Mühl H.

Int J Biochem Cell Biol. 2008;40(11):2508-21. doi: 10.1016/j.biocel.2008.04.014. Epub 2008 May 16.

PMID:
18571457
15.
16.

MAP kinase p38α regulates type III interferon (IFN-λ1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation.

Jiang M, Österlund P, Fagerlund R, Rios DN, Hoffmann A, Poranen MM, Bamford DH, Julkunen I.

J Leukoc Biol. 2015 Feb;97(2):307-20. doi: 10.1189/jlb.2A0114-059RR. Epub 2014 Dec 3.

PMID:
25473098
17.

The dysfunctional innate immune response triggered by Toll-like receptor activation is restored by TLR7/TLR8 and TLR9 ligands in cutaneous lichen planus.

Domingues R, de Carvalho GC, da Silva Oliveira LM, Futata Taniguchi E, Zimbres JM, Aoki V, da Silva Duarte AJ, Sato MN.

Br J Dermatol. 2015 Jan;172(1):48-55. doi: 10.1111/bjd.13214. Epub 2014 Nov 20.

PMID:
24976336
18.

Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis.

Shin JJ, Strle K, Glickstein LJ, Luster AD, Steere AC.

Arthritis Res Ther. 2010;12(5):R168. doi: 10.1186/ar3128. Epub 2010 Sep 9.

19.

Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines.

Gorden KK, Qiu X, Battiste JJ, Wightman PP, Vasilakos JP, Alkan SS.

J Immunol. 2006 Dec 1;177(11):8164-70.

20.

IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.

Sriram U, Xu J, Chain RW, Varghese L, Chakhtoura M, Bennett HL, Zoltick PW, Gallucci S.

PLoS One. 2014 Jan 29;9(1):e87668. doi: 10.1371/journal.pone.0087668. eCollection 2014.

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