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Items: 1 to 20 of 106

1.

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass.

Rachdi L, Kariyawasam D, Guez F, Aïello V, Arbonés ML, Janel N, Delabar JM, Polak M, Scharfmann R.

Diabetologia. 2014 May;57(5):960-9. doi: 10.1007/s00125-014-3174-3. Epub 2014 Jan 30.

PMID:
24477974
2.

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R.

Cell Cycle. 2014;13(14):2221-9. doi: 10.4161/cc.29250. Epub 2014 May 28.

3.

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.

Shen W, Taylor B, Jin Q, Nguyen-Tran V, Meeusen S, Zhang YQ, Kamireddy A, Swafford A, Powers AF, Walker J, Lamb J, Bursalaya B, DiDonato M, Harb G, Qiu M, Filippi CM, Deaton L, Turk CN, Suarez-Pinzon WL, Liu Y, Hao X, Mo T, Yan S, Li J, Herman AE, Hering BJ, Wu T, Martin Seidel H, McNamara P, Glynne R, Laffitte B.

Nat Commun. 2015 Oct 26;6:8372. doi: 10.1038/ncomms9372.

4.

Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.

Hille S, Dierck F, Kühl C, Sosna J, Adam-Klages S, Adam D, Lüllmann-Rauch R, Frey N, Kuhn C.

Cardiovasc Res. 2016 Jun 1;110(3):381-94. doi: 10.1093/cvr/cvw074. Epub 2016 Apr 7.

PMID:
27056896
5.

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbonés ML.

Dev Cell. 2008 Dec;15(6):841-53. doi: 10.1016/j.devcel.2008.10.014.

6.

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

Sitz JH, Baumgärtel K, Hämmerle B, Papadopoulos C, Hekerman P, Tejedor FJ, Becker W, Lutz B.

Neuroscience. 2008 Dec 2;157(3):596-605. doi: 10.1016/j.neuroscience.2008.09.034. Epub 2008 Oct 1.

PMID:
18938227
7.

Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.

Park JH, Jung MS, Kim YS, Song WJ, Chung SH.

J Neurochem. 2012 Sep;122(5):1081-91. doi: 10.1111/j.1471-4159.2012.07861.x. Epub 2012 Aug 3.

8.

Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.

Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW.

J Biol Chem. 2002 May 17;277(20):17597-604. Epub 2002 Mar 4.

9.

DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease.

Barallobre MJ, Perier C, Bové J, Laguna A, Delabar JM, Vila M, Arbonés ML.

Cell Death Dis. 2014 Jun 12;5:e1289. doi: 10.1038/cddis.2014.253.

10.

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation.

Soppa U, Schumacher J, Florencio Ortiz V, Pasqualon T, Tejedor FJ, Becker W.

Cell Cycle. 2014;13(13):2084-100. doi: 10.4161/cc.29104. Epub 2014 May 7.

11.

Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).

Song WJ, Song EA, Jung MS, Choi SH, Baik HH, Jin BK, Kim JH, Chung SH.

J Biol Chem. 2015 Jan 23;290(4):2321-33. doi: 10.1074/jbc.M114.594952. Epub 2014 Dec 4.

12.

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.

Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK.

Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7.

13.

MNB/DYRK1A as a multiple regulator of neuronal development.

Tejedor FJ, Hämmerle B.

FEBS J. 2011 Jan;278(2):223-35. doi: 10.1111/j.1742-4658.2010.07954.x. Epub 2010 Dec 13. Review.

14.

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

Guo X, Williams JG, Schug TT, Li X.

J Biol Chem. 2010 Apr 23;285(17):13223-32. doi: 10.1074/jbc.M110.102574. Epub 2010 Feb 18.

15.

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice.

Fotaki V, Dierssen M, Alcántara S, Martínez S, Martí E, Casas C, Visa J, Soriano E, Estivill X, Arbonés ML.

Mol Cell Biol. 2002 Sep;22(18):6636-47.

16.

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain.

Planque C, Dairou J, Noll C, Bui LC, Ripoll C, Guedj F, Delabar JM, Janel N.

J Mol Neurosci. 2013 May;50(1):1-6. doi: 10.1007/s12031-012-9835-0. Epub 2012 Jun 15.

PMID:
22700376
17.

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine.

Seifert A, Allan LA, Clarke PR.

FEBS J. 2008 Dec;275(24):6268-80. doi: 10.1111/j.1742-4658.2008.06751.x. Epub 2008 Nov 7.

18.
19.

Mechanism of dual specificity kinase activity of DYRK1A.

Walte A, Rüben K, Birner-Gruenberger R, Preisinger C, Bamberg-Lemper S, Hilz N, Bracher F, Becker W.

FEBS J. 2013 Sep;280(18):4495-511. doi: 10.1111/febs.12411. Epub 2013 Jul 22.

20.

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.

Kumar K, Man-Un Ung P, Wang P, Wang H, Li H, Andrews MK, Stewart AF, Schlessinger A, DeVita RJ.

Eur J Med Chem. 2018 Sep 5;157:1005-1016. doi: 10.1016/j.ejmech.2018.08.007. Epub 2018 Aug 22.

PMID:
30170319

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