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Items: 1 to 20 of 143

1.

The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.

Haldar AK, Piro AS, Pilla DM, Yamamoto M, Coers J.

PLoS One. 2014 Jan 17;9(1):e86684. doi: 10.1371/journal.pone.0086684. eCollection 2014.

2.

IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.

Haldar AK, Saka HA, Piro AS, Dunn JD, Henry SC, Taylor GA, Frickel EM, Valdivia RH, Coers J.

PLoS Pathog. 2013;9(6):e1003414. doi: 10.1371/journal.ppat.1003414. Epub 2013 Jun 13.

3.

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.

Haldar AK, Foltz C, Finethy R, Piro AS, Feeley EM, Pilla-Moffett DM, Komatsu M, Frickel EM, Coers J.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5628-37. doi: 10.1073/pnas.1515966112. Epub 2015 Sep 28.

4.

Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.

Haldar AK, Piro AS, Finethy R, Espenschied ST, Brown HE, Giebel AM, Frickel EM, Nelson DE, Coers J.

MBio. 2016 Dec 13;7(6). pii: e01417-16. doi: 10.1128/mBio.01417-16.

5.

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J.

Infect Immun. 2015 Dec;83(12):4740-9. doi: 10.1128/IAI.00856-15. Epub 2015 Sep 28.

6.

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy.

Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S.

Autophagy. 2016 Jul 2;12(7):1153-67. doi: 10.1080/15548627.2016.1178447. Epub 2016 May 12.

7.

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

Ohshima J, Lee Y, Sasai M, Saitoh T, Su Ma J, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M.

J Immunol. 2014 Apr 1;192(7):3328-35. doi: 10.4049/jimmunol.1302822. Epub 2014 Feb 21.

8.

Ubiquitination of pathogen-containing vacuoles promotes host defense to Chlamydia trachomatis and Toxoplasma gondii.

Coers J, Haldar AK.

Commun Integr Biol. 2015 Dec 4;8(6):e1115163. doi: 10.1080/19420889.2015.1115163. eCollection 2015 Nov-Dec.

9.

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4581-90. doi: 10.1073/pnas.1510031112. Epub 2015 Aug 3.

10.

The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.

Immunity. 2014 Jun 19;40(6):924-35. doi: 10.1016/j.immuni.2014.05.006. Epub 2014 Jun 12.

11.

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.

Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM.

PLoS One. 2011;6(9):e24434. doi: 10.1371/journal.pone.0024434. Epub 2011 Sep 8.

12.

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.

Pawlowski N, Khaminets A, Hunn JP, Papic N, Schmidt A, Uthaiah RC, Lange R, Vopper G, Martens S, Wolf E, Howard JC.

BMC Biol. 2011 Jan 28;9:7. doi: 10.1186/1741-7007-9-7.

13.

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

Khaminets A, Hunn JP, Könen-Waisman S, Zhao YO, Preukschat D, Coers J, Boyle JP, Ong YC, Boothroyd JC, Reichmann G, Howard JC.

Cell Microbiol. 2010 Jul;12(7):939-61. doi: 10.1111/j.1462-5822.2010.01443.x. Epub 2010 Jan 26.

14.

A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.

Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DC, Soldati-Favre D, Horie K, Takeda J, Takeda K.

Immunity. 2012 Aug 24;37(2):302-13. Epub 2012 Jul 12.

15.

Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.

Coers J, Bernstein-Hanley I, Grotsky D, Parvanova I, Howard JC, Taylor GA, Dietrich WF, Starnbach MN.

J Immunol. 2008 May 1;180(9):6237-45.

16.

Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii.

Johnston AC, Piro A, Clough B, Siew M, Virreira Winter S, Coers J, Frickel EM.

Cell Microbiol. 2016 Aug;18(8):1056-64. doi: 10.1111/cmi.12579. Epub 2016 Mar 10.

17.

IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy.

Al-Zeer MA, Al-Younes HM, Braun PR, Zerrahn J, Meyer TF.

PLoS One. 2009;4(2):e4588. doi: 10.1371/journal.pone.0004588. Epub 2009 Feb 26.

18.

Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions.

Lindenberg V, Mölleken K, Kravets E, Stallmann S, Hegemann JH, Degrandi D, Pfeffer K.

PLoS One. 2017 Sep 25;12(9):e0185273. doi: 10.1371/journal.pone.0185273. eCollection 2017.

19.

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii.

Howard JC, Hunn JP, Steinfeldt T.

Curr Opin Microbiol. 2011 Aug;14(4):414-21. doi: 10.1016/j.mib.2011.07.002. Epub 2011 Jul 23. Review.

PMID:
21783405
20.

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

Zhao YO, Khaminets A, Hunn JP, Howard JC.

PLoS Pathog. 2009 Feb;5(2):e1000288. doi: 10.1371/journal.ppat.1000288. Epub 2009 Feb 6.

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