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Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage.

Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO.

PLoS One. 2013 May 7;8(5):e62351. doi: 10.1371/journal.pone.0062351. Print 2013.


DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.

Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S.

Mol Pharmacol. 2004 Sep;66(3):478-91.


Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

Naumann SC, Roos WP, Jöst E, Belohlavek C, Lennerz V, Schmidt CW, Christmann M, Kaina B.

Br J Cancer. 2009 Jan 27;100(2):322-33. doi: 10.1038/sj.bjc.6604856. Epub 2009 Jan 6.


N3-substituted temozolomide analogs overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death.

Zhang J, Hummersone M, Matthews CS, Stevens MF, Bradshaw TD.

Oncology. 2015;88(1):28-48. doi: 10.1159/000366131. Epub 2014 Sep 26.


Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.

Zhang J, Stevens MF, Hummersone M, Madhusudan S, Laughton CA, Bradshaw TD.

Oncology. 2011;80(3-4):195-207. doi: 10.1159/000327837. Epub 2011 Jul 1.


Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity.

Pagani E, Falcinelli S, Pepponi R, Turriziani M, Caporaso P, Caporali S, Bonmassar E, D'Atri S.

Int J Oncol. 2007 Feb;30(2):443-51.


Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.

Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL.

Mutat Res. 2001 May 10;485(4):269-81.


Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.

Chalmers AJ, Ruff EM, Martindale C, Lovegrove N, Short SC.

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1511-9. doi: 10.1016/j.ijrobp.2009.07.1703.


Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant.

Bauer M, Goldstein M, Heylmann D, Kaina B.

PLoS One. 2012;7(6):e39956. doi: 10.1371/journal.pone.0039956. Epub 2012 Jun 29.


Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

Eich M, Roos WP, Nikolova T, Kaina B.

Mol Cancer Ther. 2013 Nov;12(11):2529-40. doi: 10.1158/1535-7163.MCT-13-0136. Epub 2013 Aug 19.


A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.

Alvino E, Castiglia D, Caporali S, Pepponi R, Caporaso P, Lacal PM, Marra G, Fischer F, Zambruno G, Bonmassar E, Jiricny J, D'Atri S.

Int J Oncol. 2006 Oct;29(4):785-97.


O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

Hermisson M, Klumpp A, Wick W, Wischhusen J, Nagel G, Roos W, Kaina B, Weller M.

J Neurochem. 2006 Feb;96(3):766-76. Epub 2006 Jan 9.


Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.

Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J.

Mol Cancer Ther. 2008 Jun;7(6):1440-9. doi: 10.1158/1535-7163.MCT-07-2116.


Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B.

Oncogene. 2007 Jan 11;26(2):186-97. Epub 2006 Jul 3.


Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.

Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL.

Mol Cancer Ther. 2009 Aug;8(8):2232-42. doi: 10.1158/1535-7163.MCT-09-0142. Epub 2009 Aug 11.


IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide.

Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, Woodcock M, Repapi E, Li JL, Middleton MR, Macaulay VM.

Oncotarget. 2015 Nov 24;6(37):39877-90. doi: 10.18632/oncotarget.5631.


CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.

Yan T, Desai AB, Jacobberger JW, Sramkoski RM, Loh T, Kinsella TJ.

Mol Cancer Ther. 2004 Sep;3(9):1147-57.

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