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Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice.

Vanzelli AS, Medeiros A, Rolim N, Bartholomeu JB, Cunha TF, Bechara LR, Gomes ER, Mattos KC, Sirvente R, Salemi VM, Mady C, Negrao CE, Guatimosim S, Brum PC.

PLoS One. 2013 May 1;8(5):e62452. doi: 10.1371/journal.pone.0062452. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/ae03273e-5ed4-4c8f-a985-b39503b2e7e5. Salemi, Vera [corrected to Salemi, Vera Maria Cury]. PLoS One. 2013;8(7). doi:10.1371/annotation/f82c53c5-e15c-470c-b5e7-7732e1435cda. Bechara, Luiz G [corrected to Bechara, Luiz R G].


Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.

Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC.

J Appl Physiol (1985). 2008 Jan;104(1):103-9.


Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.

Rolim NP, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC.

Physiol Genomics. 2007 May 11;29(3):246-52.


Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.

Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, Rosa KT, Alves MM, Medeiros A, Mattos KC, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Ramires PR, Guatimosim S, Brum PC.

J Mol Cell Cardiol. 2008 Aug;45(2):240-9. doi: 10.1016/j.yjmcc.2008.05.011.


Association of physical training with beta-blockers in heart failure in mice.

Vanzelli AS, Medeiros A, Sirvente Rde A, Salemi VM, Mady C, Brum PC.

Arq Bras Cardiol. 2010 Sep;95(3):373-80.


[Effect of carvedilol on ryanodine receptor in heart failure].

Li R, Yi QJ, Qian YR, Liu XY.

Zhonghua Er Ke Za Zhi. 2005 Aug;43(8):603-7. Chinese.


Impact of leucine supplementation on exercise training induced anti-cardiac remodeling effect in heart failure mice.

de Moraes WM, Melara TP, de Souza PR, Guimarães Fde S, Bozi LH, Brum PC, Medeiros A.

Nutrients. 2015 May 15;7(5):3751-66. doi: 10.3390/nu7053751.


Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.

Ferreira JC, Moreira JB, Campos JC, Pereira MG, Mattos KC, Coelho MA, Brum PC.

Life Sci. 2011 Mar 28;88(13-14):578-85. doi: 10.1016/j.lfs.2011.01.009.


Comparison of low and high doses of carvedilol on restoration of cardiac function and calcium-handling proteins in rat failing heart.

Sun YL, Hu SJ, Wang LH, Hu Y, Zhou JY.

Clin Exp Pharmacol Physiol. 2005 Jul;32(7):553-60.


Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol.

Guazzi M, Agostoni P, Matturri M, Pontone G, Guazzi MD.

Am Heart J. 1999 Sep;138(3 Pt 1):460-7.


Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.

Bueno CR Jr, Ferreira JC, Pereira MG, Bacurau AV, Brum PC.

J Appl Physiol (1985). 2010 Sep;109(3):702-9. doi: 10.1152/japplphysiol.00281.2010.


[Effect of carvedilol and Radix astragali on ryanodine receptor in heart failure in mice].

Li R, Zhang Q, Yi QJ.

Zhonghua Er Ke Za Zhi. 2011 Jun;49(6):433-8. Chinese.


Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats.

Sun YL, Hu SJ, Wang LH, Hu Y, Zhou JY.

Chest. 2005 Sep;128(3):1812-21.


Regression of left ventricular remodeling in chronic heart failure: Comparative and combined effects of captopril and carvedilol.

Khattar RS, Senior R, Soman P, van der Does R, Lahiri A.

Am Heart J. 2001 Oct;142(4):704-13.


Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.

Yue-Chun L, Teng Z, Na-Dan Z, Li-Sha G, Qin L, Xue-Qiang G, Jia-Feng L.

PLoS One. 2012;7(6):e39394. doi: 10.1371/journal.pone.0039394.


Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol.

Fraga R, Franco FG, Roveda F, de Matos LN, Braga AM, Rondon MU, Rotta DR, Brum PC, Barretto AC, Middlekauff HR, Negrão CE.

Eur J Heart Fail. 2007 Jun-Jul;9(6-7):630-6.


Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.

Oliveira RS, Ferreira JC, Gomes ER, Paixão NA, Rolim NP, Medeiros A, Guatimosim S, Brum PC.

J Physiol. 2009 Aug 1;587(Pt 15):3899-910. doi: 10.1113/jphysiol.2009.173948.


Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure.

Aït Mou Y, Reboul C, Andre L, Lacampagne A, Cazorla O.

Cardiovasc Res. 2009 Feb 15;81(3):555-64. doi: 10.1093/cvr/cvn229.


Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice.

Pereira MG, Ferreira JC, Bueno CR Jr, Mattos KC, Rosa KT, Irigoyen MC, Oliveira EM, Krieger JE, Brum PC.

Eur J Appl Physiol. 2009 Apr;105(6):843-50. doi: 10.1007/s00421-008-0967-4.

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