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Items: 1 to 20 of 184

1.

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL.

N Engl J Med. 2013 Apr 25;368(17):1575-84. doi: 10.1056/NEJMoa1109400.

2.

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide.

Wang Z, Tang WH, Buffa JA, Fu X, Britt EB, Koeth RA, Levison BS, Fan Y, Wu Y, Hazen SL.

Eur Heart J. 2014 Apr;35(14):904-10. doi: 10.1093/eurheartj/ehu002. Epub 2014 Feb 3.

3.

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.

Trøseid M, Ueland T, Hov JR, Svardal A, Gregersen I, Dahl CP, Aakhus S, Gude E, Bjørndal B, Halvorsen B, Karlsen TH, Aukrust P, Gullestad L, Berge RK, Yndestad A.

J Intern Med. 2015 Jun;277(6):717-26. doi: 10.1111/joim.12328. Epub 2014 Dec 1.

4.

Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure.

Tang WH, Wang Z, Shrestha K, Borowski AG, Wu Y, Troughton RW, Klein AL, Hazen SL.

J Card Fail. 2015 Feb;21(2):91-6. doi: 10.1016/j.cardfail.2014.11.006. Epub 2014 Nov 20.

5.

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control.

Mueller DM, Allenspach M, Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A.

Atherosclerosis. 2015 Dec;243(2):638-44. doi: 10.1016/j.atherosclerosis.2015.10.091. Epub 2015 Oct 24.

PMID:
26554714
6.

Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus.

Tang WH, Wang Z, Li XS, Fan Y, Li DS, Wu Y, Hazen SL.

Clin Chem. 2017 Jan;63(1):297-306. doi: 10.1373/clinchem.2016.263640. Epub 2016 Nov 18.

PMID:
27864387
7.

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL.

Nat Med. 2013 May;19(5):576-85. doi: 10.1038/nm.3145. Epub 2013 Apr 7.

8.

Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.

Obeid R, Awwad HM, Rabagny Y, Graeber S, Herrmann W, Geisel J.

Am J Clin Nutr. 2016 Mar;103(3):703-11. doi: 10.3945/ajcn.115.121269. Epub 2016 Feb 10.

9.

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.

Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL.

Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922.

10.

Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease.

Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL.

Circ Res. 2015 Jan 30;116(3):448-55. doi: 10.1161/CIRCRESAHA.116.305360. Epub 2014 Nov 5.

11.

Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine.

Stremmel W, Schmidt KV, Schuhmann V, Kratzer F, Garbade SF, Langhans CD, Fricker G, Okun JG.

PLoS One. 2017 Jan 27;12(1):e0170742. doi: 10.1371/journal.pone.0170742. eCollection 2017.

12.

Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.

Kuka J, Liepinsh E, Makrecka-Kuka M, Liepins J, Cirule H, Gustina D, Loza E, Zharkova-Malkova O, Grinberga S, Pugovics O, Dambrova M.

Life Sci. 2014 Nov 11;117(2):84-92. doi: 10.1016/j.lfs.2014.09.028. Epub 2014 Oct 7.

PMID:
25301199
13.

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease.

Missailidis C, Hällqvist J, Qureshi AR, Barany P, Heimbürger O, Lindholm B, Stenvinkel P, Bergman P.

PLoS One. 2016 Jan 11;11(1):e0141738. doi: 10.1371/journal.pone.0141738. eCollection 2016.

14.

Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis.

Tang WH, Wang Z, Fan Y, Levison B, Hazen JE, Donahue LM, Wu Y, Hazen SL.

J Am Coll Cardiol. 2014 Nov 4;64(18):1908-14. doi: 10.1016/j.jacc.2014.02.617. Epub 2014 Oct 27.

15.

Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population.

Rohrmann S, Linseisen J, Allenspach M, von Eckardstein A, Müller D.

J Nutr. 2016 Feb;146(2):283-9. doi: 10.3945/jn.115.220103. Epub 2015 Dec 16.

16.

Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events.

Kim RB, Morse BL, Djurdjev O, Tang M, Muirhead N, Barrett B, Holmes DT, Madore F, Clase CM, Rigatto C, Levin A; CanPREDDICT Investigators.

Kidney Int. 2016 May;89(5):1144-1152. doi: 10.1016/j.kint.2016.01.014. Epub 2016 Mar 19.

PMID:
27083288
17.

Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis.

Kaysen GA, Johansen KL, Chertow GM, Dalrymple LS, Kornak J, Grimes B, Dwyer T, Chassy AW, Fiehn O.

J Ren Nutr. 2015 Jul;25(4):351-6. doi: 10.1053/j.jrn.2015.02.006. Epub 2015 Mar 19.

18.

Effect of Lactobacillus casei Shirota supplementation on trimethylamine-N-oxide levels in patients with metabolic syndrome: An open-label, randomized study.

Tripolt NJ, Leber B, Triebl A, Köfeler H, Stadlbauer V, Sourij H.

Atherosclerosis. 2015 Sep;242(1):141-4. doi: 10.1016/j.atherosclerosis.2015.05.005. Epub 2015 Jul 8.

PMID:
26188537
19.

Intra-individual variation of plasma trimethylamine-N-oxide (TMAO), betaine and choline over 1 year.

Kühn T, Rohrmann S, Sookthai D, Johnson T, Katzke V, Kaaks R, von Eckardstein A, Müller D.

Clin Chem Lab Med. 2017 Feb 1;55(2):261-268. doi: 10.1515/cclm-2016-0374.

PMID:
27447240
20.

Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study.

Mafune A, Iwamoto T, Tsutsumi Y, Nakashima A, Yamamoto I, Yokoyama K, Yokoo T, Urashima M.

Clin Exp Nephrol. 2016 Oct;20(5):731-739. Epub 2015 Dec 16.

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