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Items: 1 to 20 of 106

1.

Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.

Hamilton BS, Whittaker GR.

J Biol Chem. 2013 Jun 14;288(24):17399-407. doi: 10.1074/jbc.M112.440362. Epub 2013 Apr 23.

2.

Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities.

Hamilton BS, Gludish DW, Whittaker GR.

J Virol. 2012 Oct;86(19):10579-86. doi: 10.1128/JVI.00306-12. Epub 2012 Jul 18.

3.

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.

Magnen M, Gueugnon F, Guillon A, Baranek T, Thibault VC, Petit-Courty A, de Veer SJ, Harris J, Humbles AA, Si-Tahar M, Courty Y.

J Virol. 2017 Jul 27;91(16). pii: e00421-17. doi: 10.1128/JVI.00421-17. Print 2017 Aug 15.

4.

A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site.

Straus MR, Whittaker GR.

PLoS One. 2017 Mar 30;12(3):e0174827. doi: 10.1371/journal.pone.0174827. eCollection 2017.

5.

Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.

Leu CH, Yang ML, Chung NH, Huang YJ, Su YC, Chen YC, Lin CC, Shieh GS, Chang MY, Wang SW, Chang Y, Chao J, Chao L, Wu CL, Shiau AL.

Antimicrob Agents Chemother. 2015 Sep;59(9):5619-30. doi: 10.1128/AAC.00065-15. Epub 2015 Jul 6.

6.

Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2.

Hamilton BS, Chung C, Cyphers SY, Rinaldi VD, Marcano VC, Whittaker GR.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):1070-5. doi: 10.1016/j.bbrc.2014.06.109. Epub 2014 Jun 27.

7.

Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.

Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR.

J Virol. 2013 May;87(9):5161-9. doi: 10.1128/JVI.00210-13. Epub 2013 Feb 28.

8.

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics.

Garten W, Braden C, Arendt A, Peitsch C, Baron J, Lu Y, Pawletko K, Hardes K, Steinmetzer T, Böttcher-Friebertshäuser E.

Eur J Cell Biol. 2015 Jul-Sep;94(7-9):375-83. doi: 10.1016/j.ejcb.2015.05.013. Epub 2015 Jun 1.

PMID:
26095298
9.

Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation.

Galloway SE, Reed ML, Russell CJ, Steinhauer DA.

PLoS Pathog. 2013 Feb;9(2):e1003151. doi: 10.1371/journal.ppat.1003151. Epub 2013 Feb 14.

10.

Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.

Sun X, Tse LV, Ferguson AD, Whittaker GR.

J Virol. 2010 Sep;84(17):8683-90. doi: 10.1128/JVI.00797-10. Epub 2010 Jun 16.

11.

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.

Tarnow C, Engels G, Arendt A, Schwalm F, Sediri H, Preuss A, Nelson PS, Garten W, Klenk HD, Gabriel G, Böttcher-Friebertshäuser E.

J Virol. 2014 May;88(9):4744-51. doi: 10.1128/JVI.03799-13. Epub 2014 Feb 12.

12.

Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication.

Kesic MJ, Hernandez M, Jaspers I.

Respir Res. 2012 Sep 19;13:82. doi: 10.1186/1465-9921-13-82.

13.

Activation of influenza A viruses by host proteases from swine airway epithelium.

Peitsch C, Klenk HD, Garten W, Böttcher-Friebertshäuser E.

J Virol. 2014 Jan;88(1):282-91. doi: 10.1128/JVI.01635-13. Epub 2013 Oct 23.

14.

The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.

Kühn N, Bergmann S, Kösterke N, Lambertz RLO, Keppner A, van den Brand JMA, Pöhlmann S, Weiß S, Hummler E, Hatesuer B, Schughart K.

J Virol. 2016 Apr 14;90(9):4298-4307. doi: 10.1128/JVI.02693-15. Print 2016 May.

15.

Proteolytic activation of the 1918 influenza virus hemagglutinin.

Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pöhlmann S.

J Virol. 2009 Apr;83(7):3200-11. doi: 10.1128/JVI.02205-08. Epub 2009 Jan 21.

16.

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.

Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W.

J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17.

17.

Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.

Böttcher-Friebertshäuser E, Klenk HD, Garten W.

Pathog Dis. 2013 Nov;69(2):87-100. doi: 10.1111/2049-632X.12053. Epub 2013 Jul 2. Review.

PMID:
23821437
18.

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.

Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É, Richter MV.

J Virol. 2013 Apr;87(8):4237-51. doi: 10.1128/JVI.03005-12. Epub 2013 Jan 30.

19.

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.

Böttcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W.

Vaccine. 2009 Oct 23;27(45):6324-9. doi: 10.1016/j.vaccine.2009.03.029.

PMID:
19840668
20.

The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.

Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M.

J Virol. 2014 May;88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5.

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