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Items: 1 to 20 of 144


Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.

Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ.

Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.


β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C.

Nature. 2016 Mar 31;531(7596):661-4. doi: 10.1038/nature17198. Epub 2016 Mar 23.


Crystal structure of pre-activated arrestin p44.

Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME.

Nature. 2013 May 2;497(7447):142-6. doi: 10.1038/nature12133. Epub 2013 Apr 21.


Activation-dependent conformational changes in {beta}-arrestin 2.

Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ.

J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22.


Visualization of arrestin recruitment by a G-protein-coupled receptor.

Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ.

Nature. 2014 Aug 14;512(7513):218-22. doi: 10.1038/nature13430. Epub 2014 Jun 22.


G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.

Miller WE, Houtz DA, Nelson CD, Kolattukudy PE, Lefkowitz RJ.

J Biol Chem. 2003 Jun 13;278(24):21663-71. Epub 2003 Mar 31.


The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM.

J Biol Chem. 2003 Feb 21;278(8):6258-67. Epub 2002 Dec 6.


β-arrestins and G protein-coupled receptor trafficking.

Tian X, Kang DS, Benovic JL.

Handb Exp Pharmacol. 2014;219:173-86. doi: 10.1007/978-3-642-41199-1_9. Review.


The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

Coffa S, Breitman M, Hanson SM, Callaway K, Kook S, Dalby KN, Gurevich VV.

PLoS One. 2011;6(12):e28723. doi: 10.1371/journal.pone.0028723. Epub 2011 Dec 12.


Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation.

Han M, Gurevich VV, Vishnivetskiy SA, Sigler PB, Schubert C.

Structure. 2001 Sep;9(9):869-80.


Structural biology: Active arrestin proteins crystallized.

Borshchevskiy V, Büldt G.

Nature. 2013 May 2;497(7447):45-6. doi: 10.1038/nature12096. Epub 2013 Apr 24. No abstract available.


Identification of receptor binding-induced conformational changes in non-visual arrestins.

Zhuo Y, Vishnivetskiy SA, Zhan X, Gurevich VV, Klug CS.

J Biol Chem. 2014 Jul 25;289(30):20991-1002. doi: 10.1074/jbc.M114.560680. Epub 2014 May 27.


Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1448-53. Epub 2005 Jan 25.


The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM.

Nature. 2016 Mar 31;531(7596):665-8. doi: 10.1038/nature17154. Epub 2016 Mar 23.


Arrestin interactions with G protein-coupled receptors.

Lohse MJ, Hoffmann C.

Handb Exp Pharmacol. 2014;219:15-56. doi: 10.1007/978-3-642-41199-1_2.


Molecular mechanism of phosphorylation-dependent arrestin activation.

Ostermaier MK, Schertler GF, Standfuss J.

Curr Opin Struct Biol. 2014 Dec;29:143-51. doi: 10.1016/ Epub 2014 Dec 5. Review.


Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY, Sun JP.

Nat Commun. 2015 Sep 8;6:8202. doi: 10.1038/ncomms9202.


Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK.

Khoury E, Nikolajev L, Simaan M, Namkung Y, Laporte SA.

J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.

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