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Items: 1 to 20 of 113

1.

Assembly of the yeast exoribonuclease Rrp6 with its associated cofactor Rrp47 occurs in the nucleus and is critical for the controlled expression of Rrp47.

Feigenbutz M, Jones R, Besong TM, Harding SE, Mitchell P.

J Biol Chem. 2013 May 31;288(22):15959-70. doi: 10.1074/jbc.M112.445759. Epub 2013 Apr 11.

2.

Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6.

Garland W, Feigenbutz M, Turner M, Mitchell P.

RNA. 2013 Dec;19(12):1659-68. doi: 10.1261/rna.039388.113. Epub 2013 Oct 8.

3.

The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae.

Feigenbutz M, Garland W, Turner M, Mitchell P.

PLoS One. 2013 Nov 5;8(11):e80752. doi: 10.1371/journal.pone.0080752. eCollection 2013.

4.

The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.

Schuch B, Feigenbutz M, Makino DL, Falk S, Basquin C, Mitchell P, Conti E.

EMBO J. 2014 Dec 1;33(23):2829-46. doi: 10.15252/embj.201488757. Epub 2014 Oct 15.

5.

The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation.

Costello JL, Stead JA, Feigenbutz M, Jones RM, Mitchell P.

J Biol Chem. 2011 Feb 11;286(6):4535-43. doi: 10.1074/jbc.M110.162826. Epub 2010 Dec 6.

6.

RNA degradation paths in a 12-subunit nuclear exosome complex.

Makino DL, Schuch B, Stegmann E, Baumgärtner M, Basquin C, Conti E.

Nature. 2015 Aug 6;524(7563):54-8. doi: 10.1038/nature14865. Epub 2015 Jul 29.

PMID:
26222026
7.

Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae.

Gonzales-Zubiate FA, Okuda EK, Da Cunha JPC, Oliveira CC.

J Biol Chem. 2017 Jul 21;292(29):12267-12284. doi: 10.1074/jbc.M116.772376. Epub 2017 May 24.

PMID:
28539363
8.

Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1.

Fasken MB, Laribee RN, Corbett AH.

PLoS Genet. 2015 Mar 16;11(3):e1005044. doi: 10.1371/journal.pgen.1005044. eCollection 2015 Mar.

9.

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3.

Zinder JC, Wasmuth EV, Lima CD.

Mol Cell. 2016 Nov 17;64(4):734-745. doi: 10.1016/j.molcel.2016.09.038. Epub 2016 Nov 3.

10.

The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

Fox MJ, Gao H, Smith-Kinnaman WR, Liu Y, Mosley AL.

PLoS Genet. 2015 Feb 13;11(2):e1004999. doi: 10.1371/journal.pgen.1004999. eCollection 2015.

11.

Rrp6, rrp47 and cofactors of the nuclear exosome.

Butler JS, Mitchell P.

Adv Exp Med Biol. 2011;702:91-104. doi: 10.1007/978-1-4419-7841-7_8.

PMID:
21713680
12.

Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

Wasmuth EV, Lima CD.

Mol Cell. 2012 Oct 12;48(1):133-44. doi: 10.1016/j.molcel.2012.07.012. Epub 2012 Aug 16.

13.

TRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6.

Callahan KP, Butler JS.

J Biol Chem. 2010 Feb 5;285(6):3540-7. doi: 10.1074/jbc.M109.058396. Epub 2009 Dec 2.

14.

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.

Milligan L, Decourty L, Saveanu C, Rappsilber J, Ceulemans H, Jacquier A, Tollervey D.

Mol Cell Biol. 2008 Sep;28(17):5446-57. doi: 10.1128/MCB.00463-08. Epub 2008 Jun 30.

15.

Transcriptome-wide analysis of exosome targets.

Schneider C, Kudla G, Wlotzka W, Tuck A, Tollervey D.

Mol Cell. 2012 Nov 9;48(3):422-33. doi: 10.1016/j.molcel.2012.08.013. Epub 2012 Sep 20.

16.

Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.

Wasmuth EV, Januszyk K, Lima CD.

Nature. 2014 Jul 24;511(7510):435-9. doi: 10.1038/nature13406. Epub 2014 Jul 6.

17.

Activities of human RRP6 and structure of the human RRP6 catalytic domain.

Januszyk K, Liu Q, Lima CD.

RNA. 2011 Aug;17(8):1566-77. doi: 10.1261/rna.2763111. Epub 2011 Jun 24.

18.

The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.

Heo DH, Yoo I, Kong J, Lidschreiber M, Mayer A, Choi BY, Hahn Y, Cramer P, Buratowski S, Kim M.

J Biol Chem. 2013 Dec 20;288(51):36676-90. doi: 10.1074/jbc.M113.508267. Epub 2013 Nov 6.

19.

Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus.

Carneiro T, Carvalho C, Braga J, Rino J, Milligan L, Tollervey D, Carmo-Fonseca M.

Mol Cell Biol. 2007 Jun;27(11):4157-65. Epub 2007 Apr 2.

20.

Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination.

Fox MJ, Mosley AL.

Wiley Interdiscip Rev RNA. 2016 Jan-Feb;7(1):91-104. doi: 10.1002/wrna.1317. Epub 2015 Nov 26. Review.

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