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Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X, Block TM.

Antiviral Res. 2013 Jun;98(3):432-40. doi: 10.1016/j.antiviral.2013.03.023. Epub 2013 Apr 8.


Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

Ma J, Zhang X, Soloveva V, Warren T, Guo F, Wu S, Lu H, Guo J, Su Q, Shen H, Solon E, Comunale MA, Mehta A, Guo JT, Bavari S, Du Y, Block TM, Chang J.

Antiviral Res. 2018 Feb;150:112-122. doi: 10.1016/j.antiviral.2017.12.008. Epub 2017 Dec 15.


Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

Chang J, Block TM, Guo JT.

Antiviral Res. 2013 Sep;99(3):251-60. doi: 10.1016/j.antiviral.2013.06.011. Epub 2013 Jun 29. Review.


Development of treatment strategies to combat Ebola and Marburg viruses.

Paragas J, Geisbert TW.

Expert Rev Anti Infect Ther. 2006 Feb;4(1):67-76. Review.


Drug targets in infections with Ebola and Marburg viruses.

Gene OG, Julia BE, Vanessa MR, Victoria WJ, Thomas GW, Lisa HE.

Infect Disord Drug Targets. 2009 Apr;9(2):191-200. Review.


Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.

Qu X, Pan X, Weidner J, Yu W, Alonzi D, Xu X, Butters T, Block T, Guo JT, Chang J.

Antimicrob Agents Chemother. 2011 Mar;55(3):1036-44. doi: 10.1128/AAC.01319-10. Epub 2010 Dec 20.


Novel imino sugar α-glucosidase inhibitors as antiviral compounds.

Howe JD, Smith N, Lee MJ, Ardes-Guisot N, Vauzeilles B, Désiré J, Baron A, Blériot Y, Sollogoub M, Alonzi DS, Butters TD.

Bioorg Med Chem. 2013 Aug 15;21(16):4831-8. doi: 10.1016/j.bmc.2013.03.014. Epub 2013 Mar 22.


Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists.

Cheng H, Lear-Rooney CM, Johansen L, Varhegyi E, Chen ZW, Olinger GG, Rong L.

J Virol. 2015 Oct;89(19):9932-8. doi: 10.1128/JVI.01337-15. Epub 2015 Jul 22.


Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo.

Chang J, Schul W, Butters TD, Yip A, Liu B, Goh A, Lakshminarayana SB, Alonzi D, Reinkensmeier G, Pan X, Qu X, Weidner JM, Wang L, Yu W, Borune N, Kinch MA, Rayahin JE, Moriarty R, Xu X, Shi PY, Guo JT, Block TM.

Antiviral Res. 2011 Jan;89(1):26-34. doi: 10.1016/j.antiviral.2010.11.002. Epub 2010 Nov 10.


Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

Panchal RG, Reid SP, Tran JP, Bergeron AA, Wells J, Kota KP, Aman J, Bavari S.

Antiviral Res. 2012 Jan;93(1):23-9. doi: 10.1016/j.antiviral.2011.10.011. Epub 2011 Oct 18.


Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor.

Cheng H, Schafer A, Soloveva V, Gharaibeh D, Kenny T, Retterer C, Zamani R, Bavari S, Peet NP, Rong L.

Antiviral Res. 2017 Sep;145:24-32. doi: 10.1016/j.antiviral.2017.06.015. Epub 2017 Jun 20.


Filoviruses: recent advances and future challenges.

Bray M, Pilch R.

Expert Rev Anti Infect Ther. 2006 Dec;4(6):917-21. No abstract available.


Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

Sayce AC, Alonzi DS, Killingbeck SS, Tyrrell BE, Hill ML, Caputo AT, Iwaki R, Kinami K, Ide D, Kiappes JL, Beatty PR, Kato A, Harris E, Dwek RA, Miller JL, Zitzmann N.

PLoS Negl Trop Dis. 2016 Mar 14;10(3):e0004524. doi: 10.1371/journal.pntd.0004524. eCollection 2016 Mar.


Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H, Block TM, Chang J, Guo JT.

Antimicrob Agents Chemother. 2015 Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. Epub 2014 Oct 27.


Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents.

Chang J, Guo JT, Du Y, Block T.

Emerg Microbes Infect. 2013 Nov;2(11):e77. doi: 10.1038/emi.2013.77. Epub 2013 Nov 20. Review.


Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.

Chang J, Schul W, Yip A, Xu X, Guo JT, Block TM.

Antiviral Res. 2011 Nov;92(2):369-71. doi: 10.1016/j.antiviral.2011.08.003. Epub 2011 Aug 11.


Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo.

Warfield KL, Warren TK, Qiu X, Wells J, Mire CE, Geisbert JB, Stuthman KS, Garza NL, Van Tongeren SA, Shurtleff AC, Agans KN, Wong G, Callahan MV, Geisbert TW, Klose B, Ramstedt U, Treston AM.

Antiviral Res. 2017 Feb;138:22-31. doi: 10.1016/j.antiviral.2016.11.019. Epub 2016 Nov 28.


Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses.

Chang J, Wang L, Ma D, Qu X, Guo H, Xu X, Mason PM, Bourne N, Moriarty R, Gu B, Guo JT, Block TM.

Antimicrob Agents Chemother. 2009 Apr;53(4):1501-8. doi: 10.1128/AAC.01457-08. Epub 2009 Feb 17.


Iminosugar antivirals: the therapeutic sweet spot.

Alonzi DS, Scott KA, Dwek RA, Zitzmann N.

Biochem Soc Trans. 2017 Apr 15;45(2):571-582. doi: 10.1042/BST20160182. Review.


Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever.

Smith LM, Hensley LE, Geisbert TW, Johnson J, Stossel A, Honko A, Yen JY, Geisbert J, Paragas J, Fritz E, Olinger G, Young HA, Rubins KH, Karp CL.

J Infect Dis. 2013 Jul 15;208(2):310-8. doi: 10.1093/infdis/jis921. Epub 2012 Dec 18.

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